Using pulsatile blood flow during heart surgery to prevent kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of pulsatile blood flow compared to non-pulsatile blood flow during cardiopulmonary bypass in reducing the incidence of acute kidney injury after cardiac surgery. Investigators will assess both the safety and clinical outcomes associated with each method of blood flow. The hypothesis is that pulsatile flow, which mimics the natural beating of the heart, may provide better kidney protection than the traditional non-pulsatile flow. The study will involve patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able to provide informed consent
* Scheduled for elective cardiac surgery with cardiopulmonary bypass

Exclusion Criteria

* Emergency procedures
* Scheduled for heart or lung transplantation
* Scheduled for ventricular assist device implantation
* Use of the Medtronic Elongated Once-Piece Arterial Cannula
* Diagnosed with sepsis
* Diagnosed with delirium
* Experiencing hemodynamic instability (heart rate \> 100 and systolic blood pressure \< 90)
* Requiring mechanical circulatory support
* Requiring vasoactive medications

Where it's running

• University of Colorado Hospital
  Aurora, Colorado, United States Recruiting

Study contacts

• Principal investigator: Nathan J Clendenen, MD, MS — University of Colorado, Denver
• Study coordinator: Nathan J Clendenen, MD,MS
• Email: nathan.clendenen@cuanschutz.edu
• Phone: 3037245000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.