Non-invasive prediction of low blood pressure during surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to reduce intraoperative hypotension (IOH) by utilizing a non-invasive monitoring tool called the Hypotension Prediction Index (HPI). The HPI predicts the onset of IOH up to 15 minutes in advance by analyzing blood pressure data through a machine learning algorithm. The study focuses on patients undergoing major trauma or orthopedic surgeries while under general anesthesia for more than 90 minutes. By implementing goal-directed therapy based on continuous monitoring, the study seeks to minimize complications such as acute kidney injury and myocardial injury after non-cardiac surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing major trauma or orthopedic surgery in supine position, which is defined as:

  * Reconstructive Surgery of the pelvis (e.g., stabilization of fractures)
  * Total hip arthroplasty
  * Surgery of the proximal femur (e.g., stabilization of fractures)
  * Total knee arthroplasty
  * Surgery of the spine

    * Performance of general anesthesia with planned duration of \>90min
    * Age ≥ 45 years

Exclusion Criteria:

\- Predefined exclusion criteria are:

* Planned invasive blood pressure monitoring
* Participation in another interventional study
* Pregnancy and nursing mothers
* Surgery without controlled mechanical ventilation
* ASA I or IV
* Arterial Fibrillation
* Allergy against gelantine

Where it's running

• Justus-Liebig-University of Giessen
  Giessen, Germany Recruiting

Study contacts

• Principal investigator: Michael Sander, Prof. — Justus-Liebig-University of Giessen
• Study coordinator: Emmanuel Schneck, M.D.
• Email: emmanuel.schneck@chiru.med.uni-giessen.de
• Phone: 0049 641 985 44401

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.