Mapping Kidney Damage in Acute and Chronic Kidney Disease
Official title: Spatial Elucidation of Human Acute Kidney Injury and Chronic Kidney Disease using Imaging Mass Cytometry
Funded at Yale University · NIH-11174488 · Data updated 2026-11-12
This project uses advanced imaging to create detailed maps of kidney tissue from patients with acute and chronic kidney disease to better understand these conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $359,999 |
| NIH project number | 5U01DK133768-04 |
| Project ID | NIH-11174488 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acute kidney injury who are willing to undergo a kidney biopsy and participate in the Kidney Precision Medicine Project are ideal candidates for contributing to this research.
✕Less likely to help
Patients who are not able to provide kidney tissue samples for analysis would not directly benefit from this specific research approach.
What this research studies
This project aims to understand human Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) more deeply than ever before. Researchers are using a special technique called Imaging Mass Cytometry on kidney tissue samples. This method creates a highly detailed, quantitative map of nearly all cells in the tissue, showing their type, state, and how they respond to injury and repair. By combining this with other data like cell sequencing and protein information, we hope to gain a much clearer picture of how these kidney diseases develop in people.
Why it matters
Potential benefit: If successful, this work could lead to a much better understanding of human acute and chronic kidney disease, paving the way for new and more effective treatments.
How similar studies have gone: While animal models have provided some insights, this approach uses advanced imaging on human kidney biopsies to provide a novel and highly detailed understanding of human kidney disease.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Kakade, Vijayakumar Raghurama Rao — Yale University
- Study coordinator: Kakade, Vijayakumar Raghurama Rao
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Understanding kidney injury and disease using advanced imaging techniques
This study is looking at how kidney injuries and diseases affect your kidneys by examining tiny samples from patients who choose to join, using a special imaging technique to create detailed maps of kidney cells, which will help us better understand these conditions and find better treatments for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.