Managing blood pressure to prevent kidney injury after heart surgery
Impact of Targeted Blood-pressure Management on Incidence of Acute Kidney Injury After Off-pump Coronary Artery Bypass Surgery: A Randomized Controlled Trial
This study tests if managing blood pressure more carefully during heart surgery can help prevent kidney problems afterwards.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 612 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Peking University First Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT03629418 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of targeted blood-pressure management during off-pump coronary artery bypass grafting (CABG) surgery on the incidence of acute kidney injury (AKI). It builds on previous findings that individualized blood-pressure strategies can reduce postoperative organ dysfunction in noncardiac surgeries. The trial will compare targeted blood-pressure management using norepinephrine to routine management practices. By focusing on maintaining optimal blood pressure levels, the study aims to improve patient outcomes following surgery.
Who should consider this trial
Good fit: Ideal candidates are patients aged 50 years and older scheduled for off-pump CABG surgery.
Not a fit: Patients with untreated severe hypertension, chronic kidney disease, or those requiring emergency surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of acute kidney injury in patients undergoing off-pump CABG surgery.
How similar studies have performed: Previous studies have shown success with individualized blood-pressure management in noncardiac surgeries, suggesting potential for similar outcomes in this context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 50 years; * Scheduled to undergo off-pump CABG surgery. Exclusion Criteria: * Refuse to participate; * Untreated or uncontrolled severe hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg); * Chronic kidney disease with a glomerular filtration rate \< 30 ml/min/1.73 m2 or end-stage renal disease requiring renal-replacement therapy; * Inability to communicate during the preoperative period because of coma, profound dementia, language barrier, or end-stage disease; * Requirement of vasopressors/inotropics to maintain blood pressure before surgery; * Second or emergency surgery; * Expected survival of less than 24 hours.
Where this trial is running
Beijing, Beijing Municipality
- Beijing University First Hospital — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Dong-Xin Wang, MD, PhD — Peking University First Hospital
- Study coordinator: Dong-Xin Wang, MD, PhD
- Email: wangdongxin@hotmail.com
- Phone: 8610-83572784
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.