Managing blood pressure to prevent kidney injury after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of targeted blood-pressure management during off-pump coronary artery bypass grafting (CABG) surgery on the incidence of acute kidney injury (AKI). It builds on previous findings that individualized blood-pressure strategies can reduce postoperative organ dysfunction in noncardiac surgeries. The trial will compare targeted blood-pressure management using norepinephrine to routine management practices. By focusing on maintaining optimal blood pressure levels, the study aims to improve patient outcomes following surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 50 years;
* Scheduled to undergo off-pump CABG surgery.

Exclusion Criteria:

* Refuse to participate;
* Untreated or uncontrolled severe hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg);
* Chronic kidney disease with a glomerular filtration rate \< 30 ml/min/1.73 m2 or end-stage renal disease requiring renal-replacement therapy;
* Inability to communicate during the preoperative period because of coma, profound dementia, language barrier, or end-stage disease;
* Requirement of vasopressors/inotropics to maintain blood pressure before surgery;
* Second or emergency surgery;
* Expected survival of less than 24 hours.

Where it's running

• Beijing University First Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Dong-Xin Wang, MD, PhD — Peking University First Hospital
• Study coordinator: Dong-Xin Wang, MD, PhD
• Email: wangdongxin@hotmail.com
• Phone: 8610-83572784

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.