Condition

Periodontitis clinical trials and research

• 86Clinical trials
• 65NIH research projects
• 2New in 30 days
• 33Countries

Newest Periodontitis clinical trials

All recruiting trials (86)

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• Association Between Periodontitis and Dry Eye Disease in Adults

  This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.

  Recruiting University of Sulaimani · Sulaymaniyah, As Sulaymaniyah Governorate · NCT07873697

• Periodontal Infection and Inflammatory Markers in Missed Abortion

  Researchers will test whether gum infection and inflammation are linked to missed abortion in pregnant women with no major chromosomal problems.

  Recruiting Necmettin Erbakan University · Konya, Konya · NCT07864220

• Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease

  This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.

  Recruiting Abant Izzet Baysal University · Bolu, Central · NCT07826728

• Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment

  This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.

  Recruiting Saglik Bilimleri Universitesi · Ankara and 2 other locations · NCT07822269

• Boron, Oxidative Stress, and Inflammation in Periodontitis

  This observational study compares boron levels and inflammation markers in saliva and gum tissue between people with periodontitis and healthy controls to see if boron relates to gum inflammation.

  Recruiting Marmara University · Istanbul, Maltepe · NCT07775378

• Mandibular molar furcation defects in advanced periodontitis: a regenerative treatment comparison

  In people with advanced gum disease, this study tests two regenerative treatments for Hamp Class II furcation defects in lower molars to see which works better and whether CBCT imaging matches what clinicians find during surgery.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City · NCT07770256

• A-PRF+ with Xenograft vs Collagen Membrane with Xenograft for Degree II Furcation Defects in Mandibular Molars

  This trial tests whether using advanced platelet-rich fibrin with a xenograft works better than a collagen membrane with a xenograft to treat degree II furcation defects in lower first molars of adults with periodontitis.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City, Ho Chi Minh City (HCMC) · NCT07764029

• Non-surgical periodontal treatment in periodontitis patients using MINST or quadrant-wise Q-SI

  This study tests whether minimally invasive, non-surgical periodontal care can change metabolite levels in gum fluid for people with periodontitis.

  Recruiting University of Catania · Catania, Italy · NCT07740447

• Gingival Fluid Metabolomics in Periodontitis

  This study compares the chemical makeup of fluid from the gums in people with periodontitis to those with healthy gums to see if there are distinct metabolite patterns.

  Recruiting University of Catania · Catania, Italy · NCT07739732

• Pomegranate Peel Gel as an Add-on to SRP for Stage II–III Periodontitis

  This trial tests whether applying a pomegranate peel extract gel under the gum after standard cleaning helps improve gum health in adults with Stage II–III periodontitis.

  Recruiting Al-Azhar University · Cairo, Cairo Governorate · NCT07725393

• Adjuncts to non-surgical periodontal treatment in smokers and non-smokers with periodontitis

  This trial tests whether adding I-PRF, povidone-iodine, or diode laser to standard deep cleaning helps reduce pocket depth and improve gum health in adults with periodontitis, including smokers.

  Recruiting Phase 4 Military Hospital of Tunis · Tunis, Mont Fleury · NCT07707063

• Salivary biomarkers in people with periodontitis and type 2 diabetes

  This study tests whether saliva levels of apelin, chemerin, ghrelin, and lipocalin-2 differ across people with periodontitis, type 2 diabetes, both, or neither.

  Recruiting Necmettin Erbakan University · Konya, Konya · NCT07703345

• Masticatory Performance in Adults with Periodontitis

  This study tests whether chewing performance correlates with how severe periodontitis is in adults who have the condition.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07665489

• Salivary biomarkers and periodontal disease progression

  This study tests whether certain salivary biomarkers can reflect progression from healthy gums to gingivitis and periodontitis in adults.

  Recruiting Suleyman Demirel University · Isparta · NCT07661784

• See if periodontal treatment improves chewing ability and oral quality of life

  This study tests whether treating periodontitis improves how well people can chew and how they feel about their oral health.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07651579

• SP-D in GCF: Change after MINST in periodontitis

  This study tests whether levels of Surfactant Protein D in gum fluid change after a minimally invasive non-surgical periodontal treatment in adults with periodontitis.

  Recruiting Cairo University · Cairo · NCT07599657

• Hyaluronic Acid Added to Gum Therapy for Smokers with Periodontal Disease

  This study tests whether applying hyaluronic acid gel after non-surgical gum cleaning helps smokers with periodontitis heal better than cleaning alone.

  Recruiting Marmara University · Istanbul · NCT07597213

• Periodontal Health in Rare Kidney Conditions and Controls

  This study tests how common periodontitis is in people with rare kidney disorders and compares it to CKD patients and people without kidney disease.

  Recruiting Institutul Clinic Fundeni · Bucharest · NCT07575347

• Candida albicans and periodontitis in Syrian patients

  This project will test whether Candida albicans is commonly present in the gum pockets of Syrian adults with chronic periodontitis.

  Recruiting Al-Hawash Private University · Homs · NCT07574827

• Do intelligent electric toothbrushes replace professional tooth cleaning for gum inflammation?

  We will test whether using an intelligent electric toothbrush with an oral-care routine can control gum inflammation in adults with gingivitis or early periodontitis as well as adding professional tooth cleaning.

  Recruiting Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai, Shanghai Municipality · NCT07549347

• Non-surgical gum treatment effects on saliva markers in smokers and non-smokers with periodontitis

  This test will see if deep cleaning (scaling and root planing) changes saliva markers linked to bone loss in adults with Stage II–III periodontitis, comparing current smokers and non-smokers.

  Recruiting at 2 sites Al-Mustansiriyah University · Baghdad, Baghdad Governorate and 1 other locations · NCT07547202

• Two bone graft materials with enamel matrix derivative to regenerate one- and two-wall periodontal bone defects

  This trial will test whether adding either a bovine-derived bone graft (BioOss Collagen) or a resorbable hydroxyapatite–collagen sponge (Ossix Bone) to enamel matrix derivative helps adults with one- or two-wall intrabony periodontal defects reduce pocket depth over 12 months.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan · NCT07546279

• JAK1 and JAK2 activation in healthy versus inflamed gums

  We will test whether the JAK1 and JAK2 immune-signaling pathways are more active in adults with periodontitis than in adults with healthy gums.

  Recruiting University of Chile · Santiago, Metropolitan Region · NCT07536204

• Gas6 and soluble MerTK in gum disease

  This project will test whether levels of Gas6 and soluble MerTK in gum fluid and blood are different in adults with periodontitis, gingivitis, or healthy gums.

  Recruiting Abant Izzet Baysal University · Bolu, Bolu · NCT07535177

• Diode laser–assisted gum treatment for people with kidney transplants

  This project will test whether adding a diode laser to standard deep dental cleaning (scaling and root planing) helps people with periodontitis who have had a kidney transplant.

  Recruiting at 2 sites Military Hospital 103 · Hanoi, Hadong and 1 other locations · NCT07532694

• Prodentis probiotic alongside periodontal cleaning for periodontitis

  This test will see if taking the probiotic Prodentis for up to 12 months after root surface debridement helps adults with stage III–IV periodontitis keep their gums healthier compared with taking it for only three months.

  Recruiting University of Malaya · Kuala Lumpur, Kuala Lumpur · NCT07531875

• Polynucleotide and hyaluronic acid gel with xenogeneic bone graft for treating intrabony periodontal defects

  This study tests whether adding a polynucleotide/hyaluronic acid gel plus a xenogeneic bone graft to open-flap debridement helps adults with stage III/IV periodontitis and intrabony defects heal better.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07522684

• Bioperio® protocol for treating periodontitis

  This project tests the Bioperio® protocol — professional cleaning, oral hygiene coaching, full-mouth subgingival instrumentation, and in severe pockets an enamel matrix protein application — in adults with untreated periodontitis.

  Recruiting University of Pisa · Pisa, None Selected · NCT07507474

• Oral and gum health and saliva markers in people with hepatitis B and D

  This project will test whether gum inflammation and specific saliva and gum-fluid markers differ in adults with hepatitis B and D—both those taking bulevirtide and those not—compared with healthy adults.

  Recruiting at 2 sites Research Center of Periodontal-Systemic Interactions · Craiova and 1 other locations · NCT07491848

• Minimally invasive non-surgical treatment for peri-implantitis

  This test compares a gentler, minimally invasive non-surgical cleaning (MINST) with standard non-surgical cleaning for adults who have peri-implantitis to see which gives better gum, bone, and patient-reported outcomes over 12 months.

  Recruiting St. Anne's University Hospital Brno, Czech Republic · Brno · NCT07466966

• Adding laser-based antimicrobial therapy to deep cleaning and tongue scraping for bad breath in people with type 2 diabetes and severe gum disease

  This trial tests whether adding antimicrobial photodynamic therapy to standard deep cleaning and tongue scraping reduces bad breath in people with type 2 diabetes and advanced periodontitis.

  Recruiting University of Sao Paulo · Bauru, São Paulo · NCT07463859

• Ibuprofen to reduce acute inflammation after one-stage non-surgical periodontal therapy

  This trial will test whether short-term ibuprofen lowers acute inflammatory markers (hs-CRP, ProCT, IL-6) in adults with generalized periodontitis after one-stage non-surgical periodontal therapy.

  Recruiting Phase 4 University of Baghdad · Baghdad · NCT07459049

• Vector® ultrasonic system versus mini-five curettes for non-surgical treatment of periodontitis

  This trial will test whether the Vector® ultrasonic system or manual mini-five curettes better reduce pocket depth and improve attachment in adults with Stage III–IV periodontitis.

  Recruiting Hacettepe University · Ankara · NCT07452640

• Treponema parvum in the bacteria under the gums of people with periodontitis

  This project will see if the bacteria Treponema parvum is present and how much of it is in gum-pocket samples from people with periodontitis.

  Recruiting University of Baghdad · Baghdad · NCT07443917

• Xylitol Gum to Prevent Premature Birth and Protect Baby Health

  This trial tests whether chewing xylitol gum during pregnancy reduces preterm birth and improves birth outcomes for pregnant people and their babies.

  Recruiting Phase 2/3 University of Washington · Lilongwe · NCT07424846

• Relationship Between Gum Disease and Sleep Quality

  This project will see if periodontitis and saliva inflammation markers (IL-6, IL-10, pentraxin-3) are linked to poorer sleep quality and greater fatigue in adults.

  Recruiting Uskudar University · Istanbul, Istanbul · NCT07421960

• How bacteria beneath the gums change after resective, regenerative, or peri-implant surgery

  We will test whether three types of gum and implant surgery cause different changes in the bacteria beneath the gums in adults with periodontitis or peri-implantitis.

  Recruiting University Hospital Muenster · Münster, North Rhine-Westphalia · NCT07414498

• Online self-check to identify your gum disease risk and guide preventive care

  This project will test whether an online questionnaire can accurately identify gum disease risk in adults with natural teeth.

  Recruiting Universiti Sains Malaysia · Abhā, 'Asir Region · NCT07410351

• Non‑invasive tests using photos, X‑rays, questionnaires and saliva markers to detect gum disease

  This project will test whether photos, dental X‑rays, questionnaires, and saliva/microbial markers can accurately detect gum disease in adults seeking dental care.

  Recruiting Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai, Shanghai Municipality and 2 other locations · NCT07406867

• Pilot test of a commercial toothpaste for periodontitis

  This test will see if brushing twice daily with a commercial toothpaste that contains a new ingredient helps people with periodontitis protect their oral microbiome between regular cleanings.

  Recruiting at 4 sites Periotrap Pharmaceuticals GmbH · Halle, Saxony-Anhalt and 4 other locations · NCT07397312

• Periodontal status, smoking, and salivary inflammasome markers

  This trial will test whether levels of salivary inflammasome proteins (NLRP-3, NLRP-6, NLRP-12, NLRC-5, IL-1β and IL-10) differ between people with and without periodontitis and whether smoking changes those levels.

  Recruiting Uskudar University · Istanbul · NCT07312552

• Blood and saliva markers to track gum disease and healing after non-surgical cleaning

  This project tries to see if a blood score (HALP), other blood inflammation markers, and salivary MMP-8 can help identify gum disease stage and predict healing after non-surgical periodontal cleaning in adults aged 18–65.

  Recruiting Erzincan University · Merkez, Erzincan · NCT07312045

• How the Hindi OHIP questionnaire detects quality-of-life changes after periodontal treatment

  This project will see if the Hindi version of the Oral Health Impact Profile (OHIP-P-HIN) can detect meaningful quality-of-life changes in adults with periodontitis after nonsurgical periodontal therapy.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07304596

• Mouth bacteria and carotid artery plaque vulnerability

  This project will see if mouth bacteria are linked to vulnerable carotid plaques in adults having carotid endarterectomy at Semmelweis University.

  Recruiting Semmelweis University Heart and Vascular Center · Budapest · NCT07296965

• 3-month liquid platelet-rich fibrin treatment used during deep cleaning for stage II–IV periodontitis

  This 3-month test will see if flushing diseased gum pockets with your own liquid platelet-rich fibrin after deep cleaning helps healing for people with stage II–IV periodontitis.

  Recruiting Phase 2 Mahsa University · Jenjarum, Selangor · NCT07293962

• Finding and confirming saliva biomarkers for early periodontitis

  This project tests whether saliva-based biomarkers combined with an AI app can detect early periodontitis in adults aged 18–40.

  Recruiting Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai, Shanghai Municipality · NCT07293481

• Using biological materials to repair bone defects around teeth

  This study will test whether enamel matrix, hyaluronic acid, platelet‑rich fibrin, or a bone graft can help repair intra‑bony defects around teeth in adults with periodontitis who need minimally invasive gum surgery.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams Brabant · NCT07292870

• Anti-inflammatory diet plus non-surgical gum treatment

  This research will test whether adding anti-inflammatory nutrition education to routine non-surgical periodontal therapy helps people with periodontitis who eat a pro-inflammatory diet.

  Recruiting Recep Tayyip Erdogan University Training and Research Hospital · Rize · NCT07287540

• Guided biofilm therapy's effect on gum tissue biomarkers in periodontitis

  This trial will test whether guided biofilm therapy changes gingival crevicular fluid biomarkers in adults with generalized unstable periodontitis.

  Recruiting University of Baghdad · Baghdad · NCT07286916

• Lovastatin gel under the gum plus deep cleaning for periodontitis in smokers and non-smokers

  This test sees if placing a 1.2% lovastatin gel under the gum after deep cleaning helps adults with periodontitis, comparing smokers and non-smokers.

  Recruiting Medical University of Silesia · Bielsko-Biala, Silesian Voivodeship · NCT07282756

• Digital imaging for diagnosing cavities, plaque, and gum disease

  This project will test whether panoramic X-rays, intraoral scanners, and cone-beam CT help dentists detect cavities, dental plaque, and periodontitis in adult patients.

  Recruiting at 22 sites Recherche Clinique en Odontologie (ReCOL) · Châtillon and 21 other locations · NCT07205588

• Using injectable platelet-rich fibrin with bovine bone grafts to treat intrabony periodontal defects

  This will try adding injectable platelet-rich fibrin (i-PRF) to bovine bone grafts to see if adults with stage III periodontitis and intrabony defects heal better than with grafts alone.

  Recruiting Saglik Bilimleri Universitesi · Istanbul, Üsküdar · NCT07146776

• Albumin versus hyaluronic acid scaffolds with concentrated growth factors for non-surgical periodontitis treatment

  This trial will try whether adding either an albumin-based or a hyaluronic acid scaffold combined with concentrated growth factors to deep cleaning helps adults (25–45) with stage II/III periodontitis heal better.

  Recruiting Mansoura University · Al Mansurah, Mansoura · NCT07081230

• Comparing five non-surgical gum treatments to lower systemic inflammation

  This trial tests five different non-surgical periodontal treatments to see if they lower blood inflammation markers in adults with stage III or IV periodontitis.

  Recruiting National and Kapodistrian University of Athens · Athens · NCT07077122

• Photodynamic therapy added to standard non-surgical periodontitis treatment

  This trial will test whether adding photodynamic therapy to standard scaling and root planing helps adults with periodontitis eliminate bacteria and improve gum healing more than mechanical treatment alone.

  Recruiting Egas Moniz - Cooperativa de Ensino Superior, CRL · Almada, Monte Da Caparica and 1 other locations · NCT07070453

• Platelet-rich fibrin added to deep tooth cleaning for periodontitis

  This will try adding platelet-rich fibrin (PRF) to deep non-surgical cleaning to see if it improves gum healing and attachment in adults with stage II–IV periodontitis.

  Recruiting University of Bern · Bern · NCT07013682

• Two mouthwashes for gum disease: CHX 0.2% versus CHX 0.12% + CPC

  This study tests whether a lower-concentration chlorhexidine mouthwash with CPC works as well as a standard chlorhexidine mouthwash as an extra treatment for periodontitis.

  Recruiting The University of Hong Kong · Hong Kong · NCT06967402

• Examining Salivary Cytokine Levels in Different Periodontal Conditions

  This study is trying to see if the levels of certain proteins in saliva can help us understand the differences in gum health between people with healthy gums, gingivitis, and periodontitis.

  Recruiting Izmir Katip Celebi University · Izmir, Çiğli · NCT06961409

• Using erythritol to improve gum health in severe periodontitis

  This study tests if adding erythritol powder to regular gum treatment can help people with severe periodontitis improve their gum health.

  Recruiting University of L'Aquila · L’Aquila · NCT06958874

• Improving dental care for nursing home residents to reduce infections and enhance diabetes control

  This study tests if better dental care for nursing home residents can help reduce infections and improve diabetes control.

  Recruiting Missouri Department of Health and Senior Services · Jefferson City, Missouri · NCT06890676

• TLR4 gene change and periodontitis in adults with end-stage kidney disease

  This project will test whether a specific TLR4 gene change (rs2149356) is linked to periodontitis in adults aged 30–60 who are on hemodialysis for end-stage kidney disease compared with otherwise healthy adults who also have periodontitis.

  Recruiting Ain Shams University · Al Fayyum, Faiyum Governorate · NCT06755372

• Manuka honey mouth rinse for people on hemodialysis with periodontitis

  This tests whether a Manuka honey mouth rinse can improve gum disease in adults with end-stage kidney disease who are receiving hemodialysis.

  Recruiting Phase 3 Ain Shams University · Banhā · NCT06726876

• Analyzing Gingival Color to Evaluate Periodontal Treatment Effectiveness

  This study is testing if changes in gum color can help show how well treatment works for people with gum disease.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06698718

• Using Electrolysed Saline Rinse to Help Treat Chronic Periodontitis

  This study is testing if a special saline rinse can help people with chronic gum disease get better results when used along with regular dental cleaning methods.

  Recruiting University of Ljubljana · Ljubljana · NCT06692582

• Using a laser treatment to help improve gum disease management

  This study is testing if a special laser treatment can help improve the results of regular gum disease care for people receiving standard dental cleaning.

  Recruiting at 2 sites Erchonia Corporation · Thousand Oaks, California and 1 other locations · NCT06656325

• Treatment for gum disease to slow heart valve narrowing

  This study is testing if treating gum disease can help slow down the worsening of heart valve narrowing in adults who have both aortic valve stenosis and gum issues.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT06587971

• Using laser and air polishing for treating gum disease

  This study tests if using a laser along with air polishing can help people with gum disease feel better compared to just using the laser alone.

  Recruiting Beijing Chao Yang Hospital · Beijing, Beijing Municipality · NCT06574802

• Hyaluronic acid and octenidine gel with non-surgical gum treatment

  This pilot will test whether adding a hyaluronic acid and octenidine gel to non-surgical periodontal treatment helps adults with advanced periodontitis heal faster and reduce inflammation.

  Recruiting at 2 sites Queen Mary University of London · London and 1 other locations · NCT06522438

• Using a special light treatment to manage periodontitis in diabetic patients

  This study tests whether a special light treatment can help diabetic patients manage gum health and plaque better than regular oral care methods.

  Recruiting Wellbeing Services County of Pirkanmaa · Tampere, Pirkanmaa · NCT06486012

• Using ultra-high frequency ultrasound to study gum tissue in healthy individuals and those with gingivitis

  This study is testing how ultra-high frequency ultrasound can help us see the differences in gum tissue between healthy people and those with gingivitis.

  Recruiting at 2 sites University of Pisa · Pisa, Italy and 1 other locations · NCT06480825

• Comparing three types of papilla incision techniques in periodontal surgery

  This study is testing three different ways to make cuts in the gums during periodontal surgery to see which method works best for treating gum disease.

  Recruiting Universidad de Murcia · Murcia, Murcia · NCT06428149

• Using a bone substitute material to treat furcation defects in molars

  This study is testing if adding a special bone material during surgery can help people with gum issues in their molars heal better than just the standard treatment.

  Recruiting Göteborg University · Gothenburg · NCT06270303

• Investigating gene and microbiome profiles in gum diseases

  This study is trying to see how genes and bacteria in the mouth are related to gum diseases like periodontitis and peri-implantitis in adults to help improve diagnosis and treatment.

  Recruiting Karolinska Institutet · Stockholm · NCT06262035

• Comparing two surgical methods for treating periodontitis

  This study tests which of two surgical methods works better for people with periodontitis who still have deep pockets around their teeth after initial treatment.

  Recruiting University of Florence · Florence, FI · NCT06123000

• Adding tongue scraping to initial periodontal therapy to reduce bad breath

  This will see if adding daily tongue scraping to standard initial periodontal treatment reduces bad breath in adults with generalized periodontitis.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT06091228

• Using light therapy to improve gum health in obese patients with periodontitis

  This study is testing whether adding light therapy to regular gum treatment can help improve gum health in obese patients with gum disease.

  Recruiting University of Sao Paulo · Bauru, São Paulo · NCT06073704

• Research on biological samples related to periodontitis and inflammation

  This study is collecting samples from patients with gum disease and healthy individuals to see what causes periodontitis and how to spot it early.

  Recruiting Assistance Publique - Hôpitaux de Paris · Ivry-sur-Seine · NCT06012019

• Using intraoral scanners to diagnose dental and periodontal diseases

  This study tests whether using a special 3D scanner can help dentists diagnose tooth and gum diseases more accurately and quickly than traditional methods for patients with gum issues.

  Recruiting CHU de Reims · Reims · NCT06006429

• Investigating Periodontitis in Children with Down Syndrome

  This study is trying to see how gum disease affects children with Down syndrome by looking at their immune response and comparing it to children with similar developmental challenges.

  Recruiting Assistance Publique - Hôpitaux de Paris · Ivry-sur-Seine · NCT05970965

• Using low laser therapy and hyaluronic acid to improve periodontal treatment

  This study is testing if adding low-level laser therapy or hyaluronic acid to regular gum treatment can help people with periodontitis heal better and reduce bacteria.

  Recruiting University of Ljubljana · Ljubljana · NCT05907161

• Examining the oral bacteria in elderly people with and without Alzheimer's disease

  This study is trying to see if the types of bacteria in the mouths of older adults can help us understand more about Alzheimer's disease by comparing those with the condition to those without it.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, CHU de NICE · NCT05077618

• Understanding the links between periodontitis, inflammation, and diabetes

  This study is trying to understand how periodontitis and inflammation are connected to diabetes by looking at biological samples from patients with severe gum disease and healthy people.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Ivry-sur-Seine and 1 other locations · NCT04831060

• Gum health in people hospitalized for an acute heart attack

  This project will test whether people recently hospitalized for a heart attack have worse gum disease than similar people who have not had a heart attack.

  Recruiting University of Aberdeen · Aberdeen · NCT04719026

• Surgical approach for treating advanced gum disease with grafting

  This study is testing a new surgical technique for people with advanced gum disease to see if it helps their gums heal better and improves their overall dental health.

  Recruiting Universidad de Murcia · Murcia · NCT03997578

• Comparing three techniques for periodontal reconstruction

  This study tests three different surgical methods for fixing gum issues in people with periodontitis to see which one works best for improving their dental health.

  Recruiting Universidad de Murcia · Murcia · NCT03997552

NIH-funded research (newest 40 of 65)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Grade C Periodontitis in Young People: Genetic Clues to a Severe, Early Condition

  A research team is studying why some young people develop a severe form of gum disease called Grade C periodontitis and how genetics and bacteria like Aa may contribute.

  NIH research University of Kentucky · Lexington, United States · NIH-11606527

• How HIV and HIV meds affect jaw bone and teeth

  This project looks at how HIV, its treatment, and immune changes may cause jawbone and tooth loss in people living with HIV.

  NIH research Emory University · Atlanta, United States · NIH-11596027

• Periodontitis and HIV treatment–related bone loss in the jaw and teeth

  This project studies how HIV and its treatment affect jawbone and tooth loss in people living with HIV, aiming to understand and reduce bone damage around teeth.

  NIH research Emory University · Atlanta, United States · NIH-11596026

• ICOS-Fc Therapy and Healing in Gum Disease (Periodontitis)

  A study in adults with periodontitis will test a special protein fragment called ICOS-Fc to calm gum inflammation and protect tooth-supporting bone.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11538109

• Oral-Gut–Bone Links in Periodontitis and Bone Loss

  This research explores how gum disease could affect bone health by studying the connection between the mouth, gut, and bones in adults.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11441853

• Diabetes-Driven Changes in Dendritic Cells and T Cells in Gum Disease

  This project studies how poorly controlled diabetes alters immune cells in periodontitis to worsen gum disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11432627

• Mitochondria-Targeted Regeneration of Jaw Bone in Periodontitis

  A study to help adults with periodontitis rebuild jaw bone using a novel mitochondria-smart therapy.

  NIH research University of Iowa · Iowa City, United States · NIH-11423573

• A new sublingual vaccine to prevent and treat gum disease

  A sublingual vaccine is being developed to prevent and treat periodontitis caused by specific gum pathogens, with the goal of reducing gum inflammation, tooth loss, and related health risks.

  NIH research Virtici, LLC · Seattle, UNITED STATES · NIH-11407234

• Senescent cells in the periodontal ligament as a target to prevent age-related gum and bone loss

  Aims to test whether removing aging cells in the gums can reduce bone loss from periodontal disease in adults.

  NIH research Augusta University · Augusta, United States · NIH-11398873

• Grade C Periodontitis in Young People: Understanding Who is at Risk

  Aimed at figuring out why some young people get a severe form of gum disease and which factors make them more likely to progress.

  NIH research University of Kentucky · Lexington, United States · NIH-11397347

• Why some young people get aggressive Grade C periodontitis

  This project looks at genetic, immune, and bacterial reasons why otherwise healthy young people develop rapidly progressing Grade C periodontitis (molar‑incisor pattern).

  NIH research University of Kentucky · Lexington, United States · NIH-11392061

• New anti-infective therapy to treat gum disease

  A new targeted medicine would help people with periodontitis by aiming at the bacteria that drive gum disease.

  NIH research Virtici, LLC · Seattle, UNITED STATES · NIH-11389303

• Immunometabolic Regulation of MDSCs in Periodontitis

  This project explores how immune cells linked to obesity might drive gum disease by increasing bone loss around teeth.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11377148

• Piezo1 and special blood vessels in gum disease

  A researcher is studying how a brain-like sensor in blood vessels called Piezo1 helps form special vessels in the jaw bone to reduce bone loss in periodontitis, with goals that could lead to new treatments.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11361091

• Effects of repeated gum disease on bone marrow health

  A study in adults explores how recurrent periodontitis may change stem cells in the bone marrow and influence blood health over time.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11354286

• AI-powered tools to improve periodontal diagnosis and treatment decisions

  A dental AI tool helps doctors diagnose periodontitis more accurately and tailor care for adults, using 2D/3D images and health records.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11347210

• Periodontitis and HIV therapy–related bone loss in people living with HIV

  A study exploring how HIV treatment–related immune changes can drive bone loss around the teeth in people with HIV, and how periodontitis may worsen this effect.

  NIH research Emory University · Atlanta, United States · NIH-11323448

• Understanding mouth bacteria linked to gum disease getting worse or staying stable

  This project looks at mouth bacteria over time in adults with chronic gum disease to find patterns that predict when the disease will worsen or remain stable.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11306656

• Gum disease and immune changes in Alzheimer's brains

  This project looks at whether oral infections from gum disease make Alzheimer's worse by changing brain immune cells and inflammation in older adults.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11299499

• Succinate from gum disease and its link to Alzheimer's

  Researchers are looking at whether succinate produced during gum disease causes brain inflammation that could increase Alzheimer's risk in people.

  NIH research University of Virginia · Charlottesville, United States · NIH-11299060

• How inflammasome differences in men and women affect gum disease

  This project looks at whether differences in an immune system component called the inflammasome explain why gum disease causes more severe tissue and bone loss in men than in women.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11283972

• How gum disease may reprogram immune cells and worsen diabetes and other conditions

  This project looks at whether long-term gum disease can 'train' immune cells in the bone marrow to increase body-wide inflammation that may make diabetes, heart disease, or arthritis worse.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11261532

• How diabetes makes gum disease worse

  Looking at how diabetes changes immune cells in the gums to explain why people with diabetes get more severe gum disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11261520

• Investigating how periodontitis may lead to Alzheimer's disease through succinate signaling

  This study is looking at how gum disease might be linked to Alzheimer's by checking how a certain substance in the brain, called succinate, affects brain cells and inflammation, and it's aimed at helping people understand the connection between oral health and brain health.

  NIH research University of Virginia · Charlottesville, United States · NIH-11247610

• Immune cells in gum disease and type 2 diabetes

  They will use single-cell RNA tools to look closely at immune cells in people with gum disease, especially those who also have type 2 diabetes or are Black.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11247071

• Understanding how immune cells affect bone healing in gum disease

  This study is looking into why healing takes longer for people with gum disease, focusing on certain proteins that might affect how well bones can regenerate, and it invites patients to help by sharing samples or information to improve our understanding of this process.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11179710

• Understanding how immune cells affect bone healing in gum disease

  This study is looking into why people with gum disease have a harder time healing their bones, and it needs patients to help by sharing samples or information so researchers can find out how certain proteins and immune cells affect bone recovery.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11179706

• Developing a sensor to quickly assess gum disease using saliva samples

  This study is working on a new device that can quickly check your saliva for signs of gum disease, making it easier for you to keep track of your dental health at home or in the dentist's office.

  NIH research Illinois Institute of Technology · Chicago, United States · NIH-11170093

• Why some young people get aggressive molar‑incisor gum disease

  This project looks for genetic, immune, and bacterial reasons why otherwise healthy young people develop fast‑moving Grade C molar‑incisor periodontitis.

  NIH research University of Kentucky · Lexington, United States · NIH-11168878

• Investigating how Kalirin affects bone health and periodontitis

  This study is looking at how a protein called Kalirin affects bone health, especially in people with gum disease, by using mice to see what happens to their bones when Kalirin is missing.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11165657

• Understanding Fibrin and Immune Cells in Gum Disease

  This research explores how a protein called fibrin and immune cells called neutrophils work together in gum disease, especially in severe forms.

  NIH research Harvard Medical School · Boston, United States · NIH-11160605

• Understanding Immune Cells and Metabolism in Gum Disease

  This research explores how immune cells and body metabolism are connected in gum disease, especially for adults who are also obese.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11159769

• Understanding how immune cells affect bone healing in gum disease

  This study is looking into why people with gum disease have a harder time healing their bones, and it needs your help to understand how certain immune cells might be getting in the way of recovery after treatment.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11145426

• How HIV and its treatment affect bone and tooth health

  This study is looking at how HIV and the medications used to treat it can affect bone health in the jaw, which is important for keeping your teeth healthy, and it's aimed at helping people living with HIV understand and improve their oral health.

  NIH research Emory University · Atlanta, United States · NIH-11144466

• How bacteria affect bone loss in periodontal disease

  This study is looking at how certain bacteria that cause gum disease affect bone cells in your jaw, which can lead to tooth loss, and it aims to find new ways to help people who aren't getting better with current treatments.

  NIH research Augusta University · Augusta, United States · NIH-11119127

• Understanding the role of microbial changes in gum disease progression

  This study is looking at how the bacteria in your mouth can affect gum disease, specifically periodontitis, and aims to find out which types of bacteria might show if the disease is getting worse or staying the same, so that better treatments can be developed for people with this condition.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11091621

• New injectable materials to treat gum disease and bone loss

  This study is working on new injectable treatments for gum disease that can help heal your gums and bones, making it easier for you to keep your teeth healthy and strong.

  NIH research University of Iowa · Iowa City, United States · NIH-11088276

• Epigenetic approaches to reduce gum disease and rebuild lost jaw bone

  Researchers are exploring whether drugs and microRNA tools that change gene activity can calm inflammation and help rebuild bone in adults with periodontitis.

  NIH research Tufts University Boston · Boston, United States · NIH-11086151

• Understanding how aging affects bone health and gum disease

  This study looks at how getting older affects the ability of bone marrow stem cells to heal and repair bones, especially for people with gum disease, and aims to find ways to help improve bone health in older adults.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11074045

• Investigating how calprotectin affects immune responses in gum disease

  This study is looking at how a protein called calprotectin affects the immune response to the germs that cause gum disease, which can lead to tooth loss, and it aims to find new ways to help manage this common dental issue.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11061055

Related topics

Quick answers

How many Periodontitis clinical trials are recruiting right now?

86, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 33 countries. The most sites are in Turkey (Türkiye) (15 trials), Italy (8 trials), France (8 trials), China (6 trials), Iraq (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 1, Phase 3: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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