Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Comparing three techniques for periodontal reconstruction

Official title: Non-Incised Papillae Surgical Approach (NIPSA) Versus Marginal Approach by Palatal Incision and Minimally Invasive Surgical Technique (MIST) in Periodontal Regeneration: a Ramdomized Clinical Trial

Run by Universidad de Murcia · NCT03997552 · Data updated 2026-11-12

This study tests three different surgical methods for fixing gum issues in people with periodontitis to see which one works best for improving their dental health.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment60 (estimated)
SponsorUniversidad de Murcia
Academic / other
Locations1 site (Murcia)
StatusRecruiting
StartedSeptember 6, 2019
Main results expectedDecember 1, 2026
Study endsFebruary 1, 2027
Registry record updatedFebruary 17, 2026
Trial IDNCT03997552 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients diagnosed with periodontitis who have specific periodontal lesions and pocket depths greater than 5 mm.

Probably not a fit

Patients with systemic diseases that contraindicate treatment or those with third molars or improperly treated teeth may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares three surgical techniques for periodontal reconstruction in patients with periodontitis: the Non-incised Papillae Surgical Approach (NIPSA), a marginal approach using a palatal incision, and a Minimally Invasive Surgical Technique (MIST). The aim is to evaluate the effectiveness of these approaches in treating periodontal pockets and improving patient outcomes. Participants will be assessed based on specific inclusion criteria related to their periodontal condition and pocket depth.

Why it matters

Potential benefit: If successful, this study could lead to improved surgical techniques for periodontal regeneration, enhancing recovery and outcomes for patients with periodontitis.

How similar studies have gone: Other studies have shown success with similar surgical approaches in periodontal treatment, suggesting potential for positive outcomes in this trial.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients diagnosed with periodontitis.
* plaque index and bleeding index of \< 30%.
* periodontal lesions with pocket probing depth \> 5 mm.
* intrabony defect \> 3 mm.
* intrabony defect configuration including a 1 and/or 2-wall component, always involving the buccal wall.

Exclusion Criteria:

* patients with systemic diseases that contraindicated treatment.
* third molars.
* teeth with incorrect endodontic or restorative treatment.

Where it's running

  • Centro Odontologico Del Sureste Slp
    Murcia, Spain
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.