Understanding how immune cells affect bone healing in gum disease
Official title: Osteoimmunology of Retarded Bone Regeneration in Periodontitis
Funded at Nova Southeastern University · NIH-11179706 · Data updated 2026-11-12
This study is looking into why people with gum disease have a harder time healing their bones, and it needs patients to help by sharing samples or information so researchers can find out how certain proteins and immune cells affect bone recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project start | December 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $66,342 |
| NIH project number | 3R01DE029709-05S2 |
| Project ID | NIH-11179706 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have been diagnosed with periodontitis.
✕Less likely to help
Patients with other types of dental issues unrelated to periodontitis may not benefit from this research.
What this research studies
This research investigates the reasons behind slow bone healing in patients with periodontitis, a serious gum disease. It focuses on specific proteins that may disrupt the natural process of bone regeneration after treatment. By examining the interactions between immune cells and bone cells, the study aims to uncover the molecular mechanisms that lead to impaired healing. Patients may be involved in providing samples or data to help identify these processes and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance bone regeneration in patients with periodontitis.
How similar studies have gone: Previous research has shown that understanding the immune response can lead to breakthroughs in treating bone regeneration issues, suggesting this approach has potential.
Where this research is happening
-
Nova Southeastern University
Fort Lauderdale-Davie, United States Active
Researchers
- Principal investigator: Kawai, Toshihisa — Nova Southeastern University
- Study coordinator: Kawai, Toshihisa
Related research
Other NIH-funded projects on the same topics.
-
Grade C Periodontitis in Young People: Genetic Clues to a Severe, Early Condition
A research team is studying why some young people develop a severe form of gum disease called Grade C periodontitis and how genetics and bacteria like Aa may contribute.
-
How HIV and HIV meds affect jaw bone and teeth
This project looks at how HIV, its treatment, and immune changes may cause jawbone and tooth loss in people living with HIV.
-
Periodontitis and HIV treatment–related bone loss in the jaw and teeth
This project studies how HIV and its treatment affect jawbone and tooth loss in people living with HIV, aiming to understand and reduce bone damage around teeth.
-
ICOS-Fc Therapy and Healing in Gum Disease (Periodontitis)
A study in adults with periodontitis will test a special protein fragment called ICOS-Fc to calm gum inflammation and protect tooth-supporting bone.
-
Oral-Gut–Bone Links in Periodontitis and Bone Loss
This research explores how gum disease could affect bone health by studying the connection between the mouth, gut, and bones in adults.
-
Diabetes-Driven Changes in Dendritic Cells and T Cells in Gum Disease
This project studies how poorly controlled diabetes alters immune cells in periodontitis to worsen gum disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.