Minimally invasive non-surgical treatment for peri-implantitis
Official title: Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis: A Multicenter Randomized Controlled Trial (MINST vs NSPT)
Run by St. Anne's University Hospital Brno, Czech Republic · NCT07466966 · Data updated 2026-11-12
This test compares a gentler, minimally invasive non-surgical cleaning (MINST) with standard non-surgical cleaning for adults who have peri-implantitis to see which gives better gum, bone, and patient-reported outcomes over 12 months.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 106 (estimated) |
| Sponsor | St. Anne's University Hospital Brno, Czech Republic Academic / other |
| Locations | 1 site (Brno) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | January 2028 |
| Study ends | April 2028 |
| Registry record updated | March 13, 2026 |
| Trial ID | NCT07466966 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with peri-implantitis (PPD ≥6 mm, BOP positive, bone loss ≥3 mm) with accessible implant surfaces, good plaque control (FMPS <30%, FMBS <30–35%), and no recent antibiotics, smoking, uncontrolled diabetes, pregnancy, or other exclusion criteria.
✕Probably not a fit
Patients unlikely to receive benefit include current or recent smokers, those with uncontrolled diabetes, pregnant or lactating individuals, those who used antibiotics in the past 3 months or need adjunctive antibiotics, implants considered hopeless, or implants requiring removal of the prosthetic suprastructure.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter, single-masked randomized controlled trial compares MINST — a tissue-preserving approach using delicate ultrasonic tips under magnification — with standard non-surgical peri-implant therapy that uses ultrasonic debridement plus curettes and curettage. Adults with peri-implantitis (probing depths ≥6 mm, bleeding on probing, and radiographic bone loss ≥3 mm) who meet hygiene and other criteria are randomized and followed for 12 months with seven clinic visits. Outcomes include clinical measures (probing depth, bleeding on probing), radiographic bone level changes, plaque sampling, standardized instrumentation and timing, and patient-reported outcomes including treatment time and comfort. Masked outcome assessment and standardized protocols are used to limit bias across sites.
Why it matters
Potential benefit: If successful, MINST could better control inflammation and limit bone loss while preserving soft tissue and reducing treatment time and discomfort compared with standard non-surgical therapy.
How similar studies have gone: Minimally invasive periodontal techniques have shown promise for natural teeth and limited pilot data support MINST around implants, but non-surgical peri-implant therapy overall has had mixed results, so this is a relatively novel application with limited definitive prior success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 * Peri-implantitis diagnosis (PPD \>6 mm, BOP+, bone loss ≥3 mm) * Accessible implant surface without removing suprastructure * FMPS \<30%, FMBS \<30-35% Exclusion Criteria: * Antibiotics in last 3 months * Pregnancy/lactation * Uncontrolled diabetes (HbA1c ≥7) * Long-term SPIC (\>2 years) * Previous implant therapy \<12 months * Smoking/vaping in last 12 months * Hopeless implant * Need for adjunctive antibiotics
Where it's running
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Syndenta s.r.o., Hlinky 92, 603 00 Brno, Czech Republic
Brno, Czechia Recruiting
Study contacts
- Study coordinator: MDDr. Filip Hromčík, Ph.D., MDDr., Ph.D.
- Email: filiphromcik@mail.muni.cz
- Phone: +420 607987134
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.