Minimally invasive non-surgical treatment for peri-implantitis
Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis: A Multicenter Randomized Controlled Trial (MINST vs NSPT)
This test compares a gentler, minimally invasive non-surgical cleaning (MINST) with standard non-surgical cleaning for adults who have peri-implantitis to see which gives better gum, bone, and patient-reported outcomes over 12 months.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 106 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Anne's University Hospital Brno, Czech Republic Academic / other |
| Locations | 1 site (Brno) |
| Trial ID | NCT07466966 on ClinicalTrials.gov |
What this trial studies
This multicenter, single-masked randomized controlled trial compares MINST — a tissue-preserving approach using delicate ultrasonic tips under magnification — with standard non-surgical peri-implant therapy that uses ultrasonic debridement plus curettes and curettage. Adults with peri-implantitis (probing depths ≥6 mm, bleeding on probing, and radiographic bone loss ≥3 mm) who meet hygiene and other criteria are randomized and followed for 12 months with seven clinic visits. Outcomes include clinical measures (probing depth, bleeding on probing), radiographic bone level changes, plaque sampling, standardized instrumentation and timing, and patient-reported outcomes including treatment time and comfort. Masked outcome assessment and standardized protocols are used to limit bias across sites.
Who should consider this trial
Good fit: Ideal candidates are adults with peri-implantitis (PPD ≥6 mm, BOP positive, bone loss ≥3 mm) with accessible implant surfaces, good plaque control (FMPS <30%, FMBS <30–35%), and no recent antibiotics, smoking, uncontrolled diabetes, pregnancy, or other exclusion criteria.
Not a fit: Patients unlikely to receive benefit include current or recent smokers, those with uncontrolled diabetes, pregnant or lactating individuals, those who used antibiotics in the past 3 months or need adjunctive antibiotics, implants considered hopeless, or implants requiring removal of the prosthetic suprastructure.
Why it matters
Potential benefit: If successful, MINST could better control inflammation and limit bone loss while preserving soft tissue and reducing treatment time and discomfort compared with standard non-surgical therapy.
How similar studies have performed: Minimally invasive periodontal techniques have shown promise for natural teeth and limited pilot data support MINST around implants, but non-surgical peri-implant therapy overall has had mixed results, so this is a relatively novel application with limited definitive prior success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 * Peri-implantitis diagnosis (PPD \>6 mm, BOP+, bone loss ≥3 mm) * Accessible implant surface without removing suprastructure * FMPS \<30%, FMBS \<30-35% Exclusion Criteria: * Antibiotics in last 3 months * Pregnancy/lactation * Uncontrolled diabetes (HbA1c ≥7) * Long-term SPIC (\>2 years) * Previous implant therapy \<12 months * Smoking/vaping in last 12 months * Hopeless implant * Need for adjunctive antibiotics
Where this trial is running
Brno
- Syndenta s.r.o., Hlinky 92, 603 00 Brno, Czech Republic — Brno, Czechia (Recruiting)
Study contacts
- Study coordinator: MDDr. Filip Hromčík, Ph.D., MDDr., Ph.D.
- Email: filiphromcik@mail.muni.cz
- Phone: +420 607987134
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.