Boron, Oxidative Stress, and Inflammation in Periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional study assesses whether salivary and gingival boron levels associate with oxidative stress, antioxidant defenses, and inflammatory markers in adults with Stage III-IV periodontitis compared to periodontally healthy controls. Researchers will measure boron, reactive oxygen species, total oxidant status, malondialdehyde, total antioxidant status, glutathione, superoxide dismutase, catalase, and interleukin-1 beta in saliva and gingival tissue. The study includes 60 systemically healthy, non-smoking participants (30 per group) and collects samples during routine dental procedures. Comparisons will explore potential links between boron status and periodontal inflammation and oxidative balance. Findings may illuminate whether boron status relates to periodontal disease activity in a cross-sectional framework.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Volunteering to participate in the study and signing the informed consent form
* Being between 18 and 65 years of age
* Being systemically healthy
* No antibiotic use within the last 3 months
* No periodontal treatment within the last 6 months
* Being a non-smoker or having quit smoking at least 5 years ago
* Not being pregnant or breastfeeding
* No current use of steroids, immunosuppressive drugs, or non-steroidal anti-inflammatory drugs
* No current use of medications associated with gingival enlargement, such as calcium channel blockers, phenytoin, or cyclosporine
* No regular use of boron-containing supplements or multivitamin complexes
* For the periodontally healthy group: no clinical attachment loss, bleeding on probing \<10%, probing depth ≤3 mm, no radiographic bone loss, and an indication for crown-lengthening surgery
* For the periodontitis group: diagnosis of Stage III or IV periodontitis according to the 2017 World Workshop classification and an indication for periodontal flap surgery

Exclusion Criteria:

* Incomplete or unreliable clinical measurements
* Insufficient saliva or gingival tissue sample for biochemical analyses
* Regular use of boron-containing oral care products within the last 3 months
* Regular consumption of boron-rich supplements or mineral waters
* Failure to comply with the study protocol

Where it's running

• : Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul,
  Istanbul, Maltepe, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Leyla Kuru
• Email: lkuru@marmara.edu.tr
• Phone: +905363791443

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.