Investigating Periodontitis in Children with Down Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the relationship between periodontitis and immune response in children with Down syndrome (trisomy 21). It will collect saliva and serum samples from participants to analyze different neutrophil subtypes associated with gingival inflammation. The study will involve two groups: children with Down syndrome and a control group of children with psychomotor retardation. The primary focus is on understanding how specific neutrophil phenotypes may contribute to the progression of periodontitis in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Common to all groups:

* Age: 3 to 12
* Patient affiliated to a social security program, beneficiary not covered by the AME.
* Legal representatives who speak and understand French well enough to be able to read and understand the study information.
* Legal representatives giving written consent for their child's participation in the study.

Specific:

Case Group:

* Trisomy 21 patient with gingival inflammation (subgroup 1)
* Trisomy 21 patient with healthy gingiva on intact periodontium with no history of periodontitis (subgroup 2)

Control Group: child meeting one of these criteria:

* Patient with psychomotor retardation with no known repercussions on the orofacial sphere or immunity, presenting gingival inflammation (subgroup 1)
* Patients with psychomotor retardation and no known repercussions on orofacial health or immunity, presenting gingival health on intact periodontium with no history of gingival inflammation (subgroup 2).
* Patients with no known general pathology and gingival inflammation (subgroup 3)
* Patients with no known general pathology and healthy gingiva on intact periodontium with no history of gingival inflammation (subgroup 4)

Exclusion Criteria:

Common to all groups:

* Patient having received antibiotic prophylaxis, antibiotic therapy or anti-inflammatory treatment in the 3 months prior to inclusion
* Patient included in another interventional research protocol or in a period of exclusion.
* Patient on AME
* Patients with a contraindication to the use of MEOPA:

  * Patients requiring pure oxygen ventilation
  * Intracranial hypertension
  * Unevaluated head trauma
  * New-onset, unexplained neurological abnormalities
  * Pneumothorax
  * Emphysema bubbles
  * Gas embolism
  * Diving accident
  * Abdominal gas distension, occlusion
  * Patient recently treated with ophthalmic gas (SF6, C3F8, C2F6)
  * Known, unsubstituted vitamin B12 deficiency

Specific to Trisomy 21 group:

\- Patient with no genetic diagnosis

Where it's running

• Carles-Foix Hospital
  Ivry-sur-Seine, France Recruiting

Study contacts

• Principal investigator: Marjolaine Ms GOSSET, PU-PH — Aphp
• Study coordinator: Marjolaine Ms GOSSET, PU-PH
• Email: marjolaine.gosset@aphp.fr; marjolaine.gosset@u-paris.fr
• Phone: 0149594811

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• Association Between Periodontitis and Dry Eye Disease in Adults

  This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.

  Recruiting University of Sulaimani · Sulaymaniyah, As Sulaymaniyah Governorate · NCT07873697

• Periodontal Infection and Inflammatory Markers in Missed Abortion

  Researchers will test whether gum infection and inflammation are linked to missed abortion in pregnant women with no major chromosomal problems.

  Recruiting Necmettin Erbakan University · Konya, Konya · NCT07864220

• Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease

  This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.

  Recruiting Abant Izzet Baysal University · Bolu, Central · NCT07826728

• Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment

  This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.

  Recruiting Saglik Bilimleri Universitesi · Ankara and 2 other locations · NCT07822269

• Boron, Oxidative Stress, and Inflammation in Periodontitis

  This observational study compares boron levels and inflammation markers in saliva and gum tissue between people with periodontitis and healthy controls to see if boron relates to gum inflammation.

  Recruiting Marmara University · Istanbul, Maltepe · NCT07775378

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.