Albumin versus hyaluronic acid scaffolds with concentrated growth factors for non-surgical periodontitis treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with stage II/III periodontitis will first receive standard non-surgical periodontal therapy and oral hygiene instruction, then be assigned to one of two treatment groups. One group will receive scaling and root planing plus an injection of hyaluronic acid mixed with liquid-phase concentrated growth factors into the periodontal pocket. The other group will receive scaling and root planing plus an albumin-based platelet-rich fibrin (ALB-PRF) preparation derived from the patient’s own blood and combined with concentrated growth factors. Clinical periodontal outcomes will be followed and gingival crevicular fluid will be sampled to measure the concentration and duration of growth factor release.

Why it matters

Who can join: the full rules

ii) Inclusion Criteria:

* Patients aging from 25-45 years
* Patients with stage II /III periodontitis
* Systemically free iii) Exclusion Criteria:
* Any systemic condition that may impact the study (21)
* Poor oral hygiene
* Pregnant and breastfeeding women
* Smoking patients.
* Patients received periodontal treatment in the last 6 months
* Unable to comply with study protocol

Where it's running

• Mansoura university Faculty of dentistry
  Al Mansurah, Mansoura, Egypt Recruiting

Study contacts

• Study coordinator: Husain A.jalil Alam, Bds
• Email: hussainalam@std.mans.edu.eg
• Phone: +201500838200

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• Association Between Periodontitis and Dry Eye Disease in Adults

  This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.

  Recruiting University of Sulaimani · Sulaymaniyah, As Sulaymaniyah Governorate · NCT07873697

• Periodontal Infection and Inflammatory Markers in Missed Abortion

  Researchers will test whether gum infection and inflammation are linked to missed abortion in pregnant women with no major chromosomal problems.

  Recruiting Necmettin Erbakan University · Konya, Konya · NCT07864220

• Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease

  This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.

  Recruiting Abant Izzet Baysal University · Bolu, Central · NCT07826728

• Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment

  This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.

  Recruiting Saglik Bilimleri Universitesi · Ankara and 2 other locations · NCT07822269

• Boron, Oxidative Stress, and Inflammation in Periodontitis

  This observational study compares boron levels and inflammation markers in saliva and gum tissue between people with periodontitis and healthy controls to see if boron relates to gum inflammation.

  Recruiting Marmara University · Istanbul, Maltepe · NCT07775378

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.