Albumin versus hyaluronic acid scaffolds with concentrated growth factors for non-surgical periodontitis treatment
Comparison Between the Efficacy of Albumin Versus Hyaluronic Acid Scaffold in Combination With Concentrated Growth Factors as an Adjunct to Non-surgical Treatment of Periodontitis (Randomized Controlled Clinical Trial)
This trial will try whether adding either an albumin-based or a hyaluronic acid scaffold combined with concentrated growth factors to deep cleaning helps adults (25–45) with stage II/III periodontitis heal better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 25 Years to 45 Years |
| Sex | All |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah, Mansoura) |
| Trial ID | NCT07081230 on ClinicalTrials.gov |
What this trial studies
Participants with stage II/III periodontitis will first receive standard non-surgical periodontal therapy and oral hygiene instruction, then be assigned to one of two treatment groups. One group will receive scaling and root planing plus an injection of hyaluronic acid mixed with liquid-phase concentrated growth factors into the periodontal pocket. The other group will receive scaling and root planing plus an albumin-based platelet-rich fibrin (ALB-PRF) preparation derived from the patient’s own blood and combined with concentrated growth factors. Clinical periodontal outcomes will be followed and gingival crevicular fluid will be sampled to measure the concentration and duration of growth factor release.
Who should consider this trial
Good fit: Ideal candidates are adults aged 25–45 with stage II or III periodontitis who are systemically healthy, non-smokers, not pregnant or breastfeeding, and able to comply with study visits.
Not a fit: Patients who smoke, have systemic conditions that affect healing, have poor oral hygiene, are pregnant or breastfeeding, or received periodontal treatment in the last six months are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this approach could improve pocket healing after non-surgical treatment, reduce pocket depths, and decrease the need for surgical intervention.
How similar studies have performed: Related work using hyaluronic acid and platelet-rich growth factor concentrates has shown positive effects on periodontal healing, but direct comparisons with albumin-based scaffolds are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
ii) Inclusion Criteria: * Patients aging from 25-45 years * Patients with stage II /III periodontitis * Systemically free iii) Exclusion Criteria: * Any systemic condition that may impact the study (21) * Poor oral hygiene * Pregnant and breastfeeding women * Smoking patients. * Patients received periodontal treatment in the last 6 months * Unable to comply with study protocol
Where this trial is running
Al Mansurah, Mansoura
- Mansoura university Faculty of dentistry — Al Mansurah, Mansoura, Egypt (Recruiting)
Study contacts
- Study coordinator: Husain A.jalil Alam, Bds
- Email: hussainalam@std.mans.edu.eg
- Phone: +201500838200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.