SP-D in GCF: Change after MINST in periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-group before-and-after study will measure SP-D levels in gingival crevicular fluid before treatment and again six months after minimally invasive non-surgical periodontal therapy in adults with stage II or III periodontitis. Clinical periodontal outcomes such as plaque, bleeding, pocket depth, attachment level, and recession will be recorded at baseline and follow-up, alongside patient satisfaction. GCF samples will be analyzed for SP-D using ELISA to explore whether the biomarker changes reflect treatment response alongside standard clinical measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female participants aged 18 years or older.
* Diagnosis of periodontitis, classified as stage II or stage III according to the 2018 classification system.
* Presence of at least one tooth with probing pocket depth (PPD) of 5 mm or more, clinical attachment loss (CAL), and radiographic evidence of bone loss.
* Presence of at least one intrabony defect with a radiographic intrabony component measuring 3 mm or more.

Exclusion Criteria:

* Current smokers or individuals with a history of smoking within the past year.
* Pregnant or lactating women.
* Use of systemic antibiotics or anti-inflammatory medications within the last 3 months.
* Known allergy to any materials or agents used during periodontal therapy.

Where it's running

• Faculty of Dentistry, Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Hossam Ashraf ElMasry
• Email: hossam.eldamarany@dentistry.cu.edu.eg
• Phone: +201129559757

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.