Gum health in people hospitalized for an acute heart attack
Official title: PERIODONTAL HEALTH IN PATIENTS ACUTELY ADMITTED FOR MYOCARDIAL INFARCTION: A CASE CONTROL STUDY
Run by University of Aberdeen · NCT04719026 · Data updated 2026-11-12
This project will test whether people recently hospitalized for a heart attack have worse gum disease than similar people who have not had a heart attack.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 90 Years |
| Sex | All |
| Enrollment | 320 (estimated) |
| Sponsor | University of Aberdeen Academic / other |
| Locations | 1 site (Aberdeen) |
| Status | Recruiting |
| Started | February 16, 2018 |
| Main results expected | March 14, 2027 |
| Study ends | March 14, 2027 |
| Registry record updated | May 8, 2026 |
| Trial ID | NCT04719026 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 20–90 who either were recently hospitalized for an acute myocardial infarction or are dental patients without prior heart attack who can be matched for age, gender and cardiovascular risk factors.
✕Probably not a fit
Patients with severe comorbidities, inability to consent, pregnancy, systemic inflammatory diseases, recent antibiotic use, certain gum-affecting medications, immunocompromise, malignancy, or specific hypersensitivities will be excluded and are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational case-control comparison of full-mouth periodontal health in adults admitted with acute myocardial infarction versus matched dental patient controls. Cases are adults aged 20–90 recently hospitalized for acute MI and controls are dental patients matched by age, gender (±7 years) and coronary artery disease risk factors. All participants receive a computerized full-mouth periodontal examination using a Florida probe, and known confounders and exclusion criteria (recent antibiotics, systemic inflammatory diseases, certain medications, pregnancy, severe comorbidities) are applied. The goal is to determine whether periodontitis is more prevalent or severe during the acute phase of MI after rigorous matching for other CAD risks.
Why it matters
Potential benefit: If results show a link between worse gum health and acute heart attacks, it could support targeting periodontal disease as part of heart-attack prevention or risk-reduction strategies.
How similar studies have gone: Several clinical and preclinical studies have reported links between periodontal disease and coronary artery disease, but few have examined periodontal status during the immediate acute phase of myocardial infarction, so aspects of this approach are novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * cases: Patients aged 20-90 admitted with acute myocardial infarction * controls: Dental patients, aged 20-90, matched to patients in the case study group for age, gender (±7) and risk factors for coronary artery disease (hypertension, obesity, diabetes, smoking, hypercholesterolaemia) but with no history of myocardial infarction) Exclusion Criteria: * Severe co-morbidities, Inability to consent, pregnant participants will be excluded, participants with other systemic inflammatory diseases, patients taking antimicrobials or antibiotics in last three years, patients taking medications, such as cyclosporine, calcium channel blockers, phenytoin, immunocompromised patients, patients with malignancies, patinets with type-2 or type-3 hypersensitivities
Where it's running
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Dr Karolin Hijazi
Aberdeen, United Kingdom Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.