Examining the oral bacteria in elderly people with and without Alzheimer's disease
Oral Bacterial and Viral Mapping by Dental Plaque in Elderly Patients With and Without Alzheimer's Disease(ORal MICrobiology in Alzheimer's Patients)
This study is trying to see if the types of bacteria in the mouths of older adults can help us understand more about Alzheimer's disease by comparing those with the condition to those without it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 94 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Nice, CHU de NICE) |
| Trial ID | NCT05077618 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the periodontal microbiota in elderly individuals, specifically focusing on those diagnosed with Alzheimer's disease compared to those without. By collecting dental plaque and blood samples, researchers hope to identify oral infectious markers that may indicate the development or progression of neurodegenerative diseases. The study seeks to map the oral microbial flora to enhance understanding and potentially control the evolution of Alzheimer's disease. The ultimate goal is to characterize oral pathogens significantly associated with Alzheimer's.
Who should consider this trial
Good fit: Ideal candidates are elderly individuals aged 70 and older, with a diagnosis of possible or probable Alzheimer's disease.
Not a fit: Patients with other neurodegenerative disorders or significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to early diagnostic markers for Alzheimer's disease through oral health assessments.
How similar studies have performed: While the approach of linking oral health to neurodegenerative diseases is gaining interest, this specific study's methodology is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ge greater than or equal to 70 years old * Patient (or trusted person) having read and understood the study information note and signed the informed consent form * Membership in a social security scheme * for cases : Diagnosis of possible or probable Alzheimer's disease according to the DSM-V Exclusion Criteria: * Presence of a neurodegenerative pathology (excluding Alzheimer's disease for cases) * Presence of a neurocognitive disorder (excluding Alzheimer's disease for the cases) * Patient with or having had any kind of cancer, including oral or aerodigestive tract * Patients with or having had autoimmune diseases (HIV, hepatitis) * Patients with inflammatory diseases (such as rheumatoid arthritis (RA) or Gougerot-Sjogren's syndrome (GSJ)) * Patients with severe haemopathy * Patients with severe acute or chronic cardiovascular, renal, hepatic, gastrointestinal, allergic, endocrine, pulmonary, neuropsychiatric pathologies, judged by the investigator to be incompatible with the study, as all these pathologies may interfere with the results of the oral flora sampling * Patients who have undergone oral surgery in the two months prior to sampling * Patients treated with oral retinoids, bisphosphonates, oral anticoagulants or anticonvulsants * Patients who have had anti-cancer or immunosuppressive chemotherapy within the last 6 months * Patient who has had antibiotic or anti-inflammatory treatment in the last 4 weeks * A history of treatments (drugs and probiotics) taken in the month prior to sampling will be taken, as well as a record of toxic habits (tobacco, alcohol, other)
Where this trial is running
Nice, CHU de NICE
- CHU de Nice — Nice, CHU de NICE, France (Recruiting)
Study contacts
- Principal investigator: Leslie BORSA — Centre Hospitalier Universitaire de Nice
- Study coordinator: Leslie Borsa
- Email: causeret.m@chu-nice.fr
- Phone: 0492034702
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.