Examining the oral bacteria in elderly people with and without Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze the periodontal microbiota in elderly individuals, specifically focusing on those diagnosed with Alzheimer's disease compared to those without. By collecting dental plaque and blood samples, researchers hope to identify oral infectious markers that may indicate the development or progression of neurodegenerative diseases. The study seeks to map the oral microbial flora to enhance understanding and potentially control the evolution of Alzheimer's disease. The ultimate goal is to characterize oral pathogens significantly associated with Alzheimer's.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ge greater than or equal to 70 years old
* Patient (or trusted person) having read and understood the study information note and signed the informed consent form
* Membership in a social security scheme
* for cases : Diagnosis of possible or probable Alzheimer's disease according to the DSM-V

Exclusion Criteria:

* Presence of a neurodegenerative pathology (excluding Alzheimer's disease for cases)
* Presence of a neurocognitive disorder (excluding Alzheimer's disease for the cases)
* Patient with or having had any kind of cancer, including oral or aerodigestive tract
* Patients with or having had autoimmune diseases (HIV, hepatitis)
* Patients with inflammatory diseases (such as rheumatoid arthritis (RA) or Gougerot-Sjogren's syndrome (GSJ))
* Patients with severe haemopathy
* Patients with severe acute or chronic cardiovascular, renal, hepatic, gastrointestinal, allergic, endocrine, pulmonary, neuropsychiatric pathologies, judged by the investigator to be incompatible with the study, as all these pathologies may interfere with the results of the oral flora sampling
* Patients who have undergone oral surgery in the two months prior to sampling
* Patients treated with oral retinoids, bisphosphonates, oral anticoagulants or anticonvulsants
* Patients who have had anti-cancer or immunosuppressive chemotherapy within the last 6 months
* Patient who has had antibiotic or anti-inflammatory treatment in the last 4 weeks
* A history of treatments (drugs and probiotics) taken in the month prior to sampling will be taken, as well as a record of toxic habits (tobacco, alcohol, other)

Where it's running

• CHU de Nice
  Nice, CHU de NICE, France Recruiting

Study contacts

• Principal investigator: Leslie BORSA — Centre Hospitalier Universitaire de Nice
• Study coordinator: Leslie Borsa
• Email: causeret.m@chu-nice.fr
• Phone: 0492034702

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.