3-month liquid platelet-rich fibrin treatment used during deep cleaning for stage II–IV periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a split-mouth interventional Phase 2 approach where half of a participant's diseased sites are irrigated with liquid platelet-rich fibrin (prepared from 20 mL of the participant's blood) and the other half are irrigated with saline during scaling and root debridement. Participants receive baseline exams, panoramic X-rays, oral hygiene instruction, and custom guides, then undergo a single-session deep cleaning with local anesthesia when the irrigations are applied. The liquid platelet-rich fibrin is prepared by spinning the participant's blood and then used to flush selected periodontal pockets, with saline used in comparator sites. Participants are followed with monthly reviews for 3 months to monitor healing, pocket depth changes, and clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have at least 20 teeth,
* American Society of Anesthesiology class I or II
* Periodontitis stages II-IV
* Bilateral sites of deep periodontal pockets ≥5 mm

Exclusion Criteria:

* Limited mouth opening or symptomatic temporomandibular joint disorder
* Inability to tolerate extended long periodontal treatment and/or hyperactive gag reflex
* Current or former smoker or vape user
* Pregnant and/or breastfeeding
* Having diabetes mellitus type I or II
* Having bleeding disorder or is on anticoagulants
* Underwent periodontal treatment and/or surgery in past 6 months prior
* Undergoing orthodontic therapy, or completed in past 3 months prior
* On or had anti-inflammatory drug(s) in past 3 months prior
* On or had antibiotic(s) in past 3 months prior
* Having autoimmune disorder
* On or had immunosuppressant drug(s) in past 3 months prior
* Undergoing or underwent radio- and/or chemo-therapy

Where it's running

• Faculty of Dentistry, MAHSA University
  Jenjarum, Selangor, Malaysia Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.