3-month liquid platelet-rich fibrin treatment used during deep cleaning for stage II–IV periodontitis
Liquid S-Platelet Rich Fibrin as a Potential Adjunct in Conservative Closed Periodontal Debridement for Periodontitis Stages II-IV: A Randomized, Split-mouth, 3-month Clinical Trial
This 3-month test will see if flushing diseased gum pockets with your own liquid platelet-rich fibrin after deep cleaning helps healing for people with stage II–IV periodontitis.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 14 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Mahsa University Academic / other |
| Locations | 1 site (Jenjarum, Selangor) |
| Trial ID | NCT07293962 on ClinicalTrials.gov |
What this trial studies
This is a split-mouth interventional Phase 2 approach where half of a participant's diseased sites are irrigated with liquid platelet-rich fibrin (prepared from 20 mL of the participant's blood) and the other half are irrigated with saline during scaling and root debridement. Participants receive baseline exams, panoramic X-rays, oral hygiene instruction, and custom guides, then undergo a single-session deep cleaning with local anesthesia when the irrigations are applied. The liquid platelet-rich fibrin is prepared by spinning the participant's blood and then used to flush selected periodontal pockets, with saline used in comparator sites. Participants are followed with monthly reviews for 3 months to monitor healing, pocket depth changes, and clinical outcomes.
Who should consider this trial
Good fit: Adults with stage II–IV periodontitis who have at least 20 teeth, bilateral periodontal pockets ≥5 mm, are ASA class I–II, non-smokers, and able to attend follow-ups at MAHSA University are ideal candidates.
Not a fit: People who smoke or vape, have diabetes, bleeding disorders, are pregnant or breastfeeding, are on anticoagulants or recent antibiotics/anti-inflammatories, or cannot tolerate extended periodontal treatment are unlikely to benefit or are excluded.
Why it matters
Potential benefit: If successful, using a person's own liquid platelet-rich fibrin could improve gum pocket healing and reduce pocket depths after deep cleaning.
How similar studies have performed: Prior clinical work with platelet-rich fibrin and related platelet concentrates in periodontal care has shown promising but mixed improvements in healing and pocket reduction.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Have at least 20 teeth, * American Society of Anesthesiology class I or II * Periodontitis stages II-IV * Bilateral sites of deep periodontal pockets ≥5 mm Exclusion Criteria: * Limited mouth opening or symptomatic temporomandibular joint disorder * Inability to tolerate extended long periodontal treatment and/or hyperactive gag reflex * Current or former smoker or vape user * Pregnant and/or breastfeeding * Having diabetes mellitus type I or II * Having bleeding disorder or is on anticoagulants * Underwent periodontal treatment and/or surgery in past 6 months prior * Undergoing orthodontic therapy, or completed in past 3 months prior * On or had anti-inflammatory drug(s) in past 3 months prior * On or had antibiotic(s) in past 3 months prior * Having autoimmune disorder * On or had immunosuppressant drug(s) in past 3 months prior * Undergoing or underwent radio- and/or chemo-therapy
Where this trial is running
Jenjarum, Selangor
- Faculty of Dentistry, MAHSA University — Jenjarum, Selangor, Malaysia (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.