Mitochondria-Targeted Regeneration of Jaw Bone in Periodontitis
Official title: Mitochondria-Targeted Immunometabolic Regeneration of Alveolar Bone in Periodontitis
Funded at University of Iowa · NIH-11423573 · Data updated 2026-11-12
A study to help adults with periodontitis rebuild jaw bone using a novel mitochondria-smart therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | August 6, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $540,583 |
| NIH project number | 1R01DE036166-01 |
| Project ID | NIH-11423573 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with periodontitis or alveolar bone loss who are candidates for regenerative therapy.
✕Less likely to help
People without periodontitis or who have conditions not addressed by this approach may not benefit.
What this research studies
If you have periodontitis, this research aims to boost the energy powerhouses in bone-forming cells to reduce inflammation and encourage bone regrowth in the jaw. The team will use alpha-ketoglutarate–based nanoparticles designed to be taken up by osteoblasts, supporting healthier bone regeneration where bone loss has occurred. The approach focuses on restoring energy flow and lowering chronic inflammation to improve outcomes after dental problems like tooth loss or implant failure. This work is being led by Sun at the University of Iowa and is tested in models relevant to human jawbone biology.
Why it matters
Potential benefit: If successful, the therapy could improve bone regeneration around teeth and dental implants, potentially reducing tooth loss and implant failures.
How similar studies have gone: Preliminary studies with AKG-based nanoparticles show promise in promoting osteoblastic activity and bone regeneration.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Sun, Hongli — University of Iowa
- Study coordinator: Sun, Hongli
Related research
Other NIH-funded projects on the same topics.
-
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-
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This project studies how poorly controlled diabetes alters immune cells in periodontitis to worsen gum disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.