Condition

Periodontal Diseases clinical trials and research

• 38Clinical trials
• 6NIH research projects
• 1New in 30 days
• 18Countries

Newest Periodontal Diseases clinical trials

All recruiting trials (38)

• Effect of Periodontal Therapy on Gut Microbes and Inflammation in People with Inflammatory Bowel Disease

  This study tests whether treating gum disease in people with inflammatory bowel disease can influence the gut microbiome and markers of systemic inflammation.

  Recruiting University of Turin, Italy · Turin, Turin · NCT07905859

• Bacterial Diversity in Gum Health With Fixed vs Removable Retainers After Braces

  This study tests the gum microbiome and gum health in adults after braces, comparing fixed lingual retainers to removable Essix retainers.

  Recruiting Universidad de Murcia · Murcia · NCT07718061

• Hyperuricemia and gum disease: is uric acid linked to bone loss in periodontitis?

  This observational study tests whether high uric acid levels are related to periodontitis and alveolar bone loss in adults.

  Recruiting Recep Tayyip Erdogan University Training and Research Hospital · Rize · NCT07666126

• See if periodontal treatment improves chewing ability and oral quality of life

  This study tests whether treating periodontitis improves how well people can chew and how they feel about their oral health.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07651579

• Vitamin D and the body's anti-inflammatory response in gum disease

  This study tests whether vitamin D can modulate the body's anti-inflammatory response in people with gum disease.

  Recruiting Recep Tayyip Erdogan University Training and Research Hospital · Rize · NCT07636733

• Candida albicans and periodontitis in Syrian patients

  This project will test whether Candida albicans is commonly present in the gum pockets of Syrian adults with chronic periodontitis.

  Recruiting Al-Hawash Private University · Homs · NCT07574827

• JAK1 and JAK2 activation in healthy versus inflamed gums

  We will test whether the JAK1 and JAK2 immune-signaling pathways are more active in adults with periodontitis than in adults with healthy gums.

  Recruiting University of Chile · Santiago, Metropolitan Region · NCT07536204

• Online self-check to identify your gum disease risk and guide preventive care

  This project will test whether an online questionnaire can accurately identify gum disease risk in adults with natural teeth.

  Recruiting Universiti Sains Malaysia · Abhā, 'Asir Region · NCT07410351

• Markers of Bone Destruction and Oxidative Stress in Peri-implantitis

  This study tests whether saliva and peri-implant sulcular fluid reflect bone loss and inflammation in peri-implantitis, periodontitis, and healthy teeth to help with early detection.

  Recruiting Saglik Bilimleri Universitesi · Keçiören, Ankara · NCT07397884

• Blood and saliva markers to track gum disease and healing after non-surgical cleaning

  This project tries to see if a blood score (HALP), other blood inflammation markers, and salivary MMP-8 can help identify gum disease stage and predict healing after non-surgical periodontal cleaning in adults aged 18–65.

  Recruiting Erzincan University · Merkez, Erzincan · NCT07312045

• Lovastatin gel under the gum plus deep cleaning for periodontitis in smokers and non-smokers

  This test sees if placing a 1.2% lovastatin gel under the gum after deep cleaning helps adults with periodontitis, comparing smokers and non-smokers.

  Recruiting Medical University of Silesia · Bielsko-Biala, Silesian Voivodeship · NCT07282756

• Keeping gums healthy after periodontal treatment with sodium bicarbonate toothpaste

  This study will test whether daily use of a sodium bicarbonate fluoride toothpaste helps adults who have had non-surgical periodontal treatment keep their gums healthy over six months.

  Recruiting University of Plymouth · Plymouth · NCT07274189

• Salivary biomarker panel to predict periodontal health over 2 years

  A 2-year observational study will test whether a panel of saliva biomarkers can predict periodontal health status in adults with varying periodontal conditions.

  Recruiting at 2 sites Universidad Complutense de Madrid · Madrid and 1 other locations · NCT07167771

• Regular home use of dual-light antibacterial photodynamic therapy plus a powered toothbrush for older adults with periodontitis and mild cognitive impairment

  This trial tests whether a dual-light antibacterial photodynamic therapy plus a powered toothbrush, compared with standard care, improves gum health and halitosis in people aged 60 and older with periodontitis and mild cognitive impairment.

  Recruiting Blekinge Institute of Technology · Karlskrona, Blekinge County and 1 other locations · NCT07166224

• Using injectable platelet-rich fibrin with bovine bone grafts to treat intrabony periodontal defects

  This will try adding injectable platelet-rich fibrin (i-PRF) to bovine bone grafts to see if adults with stage III periodontitis and intrabony defects heal better than with grafts alone.

  Recruiting Saglik Bilimleri Universitesi · Istanbul, Üsküdar · NCT07146776

• Using a surgical microscope to improve gum flap healing

  This study will test whether using a digital surgical microscope helps adults needing periodontal flap surgery heal better than using dental loupes.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT07054008

• Examining Salivary Cytokine Levels in Different Periodontal Conditions

  This study is trying to see if the levels of certain proteins in saliva can help us understand the differences in gum health between people with healthy gums, gingivitis, and periodontitis.

  Recruiting Izmir Katip Celebi University · Izmir, Çiğli · NCT06961409

• Using specialized MRI for dental imaging

  This study is testing a new type of MRI specifically for dental imaging to see if it can better diagnose dental problems compared to regular imaging methods.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06948162

• Filling intrabony periodontal defects with a volume-stable collagen matrix versus bovine bone mineral with 10% collagen

  This trial will test whether a volume-stable collagen matrix or a deproteinized bovine bone graft with 10% collagen better helps adults with advanced periodontitis heal their intrabony defects.

  Recruiting University of Bern · Bern · NCT06676826

• Using a laser treatment to help improve gum disease management

  This study is testing if a special laser treatment can help improve the results of regular gum disease care for people receiving standard dental cleaning.

  Recruiting at 2 sites Erchonia Corporation · Thousand Oaks, California and 1 other locations · NCT06656325

• Improving Oral Health for Older Adults in Primary Care

  This study is testing whether better training for doctors and changes to their systems can help older adults on Medicaid get more dental care and improve their oral health.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT06555029

• Using a special light treatment to manage periodontitis in diabetic patients

  This study tests whether a special light treatment can help diabetic patients manage gum health and plaque better than regular oral care methods.

  Recruiting Wellbeing Services County of Pirkanmaa · Tampere, Pirkanmaa · NCT06486012

• Comparing three types of papilla incision techniques in periodontal surgery

  This study is testing three different ways to make cuts in the gums during periodontal surgery to see which method works best for treating gum disease.

  Recruiting Universidad de Murcia · Murcia, Murcia · NCT06428149

• Using Telehealth to Enhance Oral Health for Cancer Survivors

  This study tests whether using telehealth can help cancer survivors improve their oral health and prevent problems after their treatment.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT06315855

• Treatment of gum defects using hyaluronic acid and polynucleotides

  This study is testing if adding a special gel to gum surgery helps people with gum disease heal better and faster.

  Recruiting at 2 sites Queen Mary University of London · London and 1 other locations · NCT06309719

• Analyzing changes in oral microbiome during dental implant placement

  This study looks at how the bacteria in the mouth change when people with severe gum disease get dental implants and whether different implant materials affect these changes.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT06149585

• Improving oral health during pregnancy to prevent complications

  This study tests if treating gum disease in pregnant women can help their babies grow better and lower the chances of early delivery.

  Recruiting at 3 sites University Hospital Bispebjerg and Frederiksberg · Holbæk, Holbaek and 2 other locations · NCT06110143

• Using AI and counseling to improve dental care for periodontal disease

  This study is testing if using AI dental monitoring alone or with counseling can help people aged 35-65 with periodontal disease improve their oral health over six months.

  Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung City · NCT06083649

• Biologic agents added to non-surgical periodontal therapy for intrabony defects

  This study tests whether adding rhPDGF, L-PRF, or enamel matrix derivatives to minimally invasive non-surgical therapy helps restore deep bone defects in periodontitis patients.

  Recruiting G. d'Annunzio University · Tirana · NCT05858411

• Comparing Novosyn and Monosyn sutures in gum surgery

  This study is testing if two types of stitches used in gum surgery help wounds heal just as well in adults.

  Recruiting Aesculap AG · Sant Cugat del Vallès, Catalonia · NCT05813236

• New surgical approach for treating periodontal disease

  This study is testing a new surgical method for treating gum disease to see if it works better than a standard technique by looking at how well patients heal over a year.

  Recruiting Universidad de Murcia · Murcia · NCT05533528

• Using a new dental gel to improve gum health after cleaning

  This study is testing if a new dental gel can help people with gum disease get even better results after their teeth cleaning treatment.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05384132

• Assessing quality of life in periodontitis patients during supportive therapy

  This study looks at how supportive therapy affects the quality of life for people with gum disease over a period of up to 10 years.

  Recruiting Medical University of Vienna · Vienna · NCT05339178

• Using antibiotics to enhance periodontal treatment effectiveness

  This study is testing different antibiotic treatments to see which ones can help people with gum disease get better after their teeth cleaning.

  Recruiting Phase 4 University of Geneva, Switzerland · Geneva, Canton of Geneva · NCT04669717

• Using AI to improve plaque control and periodontal treatment outcomes

  This study is testing whether using an AI tool for weekly dental checks can help people with gum disease improve their oral health compared to those who don’t use the tool.

  Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung City · NCT04567030

• Using patients' own blood to treat gum disease

  This study is testing whether using a treatment made from patients' own blood can help people with gum disease heal better than a traditional bone graft.

  Recruiting Queen Mary University of London · London · NCT04254861

• Comparing three techniques for periodontal reconstruction

  This study tests three different surgical methods for fixing gum issues in people with periodontitis to see which one works best for improving their dental health.

  Recruiting Universidad de Murcia · Murcia · NCT03997552

• A large health study in Hamburg focusing on chronic diseases

  This study is trying to find out what causes chronic diseases by looking at the health and lifestyle of 45,000 people aged 45 to 74 in Hamburg, Germany, and checking in with them over time.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT03934957

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Oral bacteria, gum disease, and oral HPV in people living with HIV

  This project looks at how the mouth’s bacteria and gum disease relate to oral HPV in people with HIV, and what immune factors might be involved.

  NIH research Emory University · Atlanta, United States · NIH-11384763

• Predicting Gum Disease with Advanced Models

  This project aims to create better ways to predict gum disease by looking at patient health information and oral bacteria.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11159438

• Mouth bacteria, gum disease, and oral HPV in people living with HIV

  This project looks at whether mouth bacteria and gum disease are linked to getting or keeping oral HPV in people living with HIV.

  NIH research Emory University · Atlanta, United States · NIH-11158633

• Examining the links between tooth decay and gum disease

  This study is looking at how tooth decay and gum disease are connected and how things like age, gender, and income might play a role, so we can find better ways to take care of your dental health.

  NIH research University of Florida · Gainesville, United States · NIH-11130505

• Predicting periodontal diseases using advanced modeling techniques

  This study is working on a new way to predict gum diseases using advanced technology and teamwork among health experts, so that both students and faculty can learn how to better care for patients' gum health.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-10928823

• The connection between oral bacteria, gum disease, and HPV infection in people with HIV

  This study is looking at how the bacteria in your mouth and gum diseases might affect HPV infections in people living with HIV, and it wants to learn how social factors play a role in this, so we can better understand why HPV-related cancers are more common in this group.

  NIH research Emory University · Atlanta, United States · NIH-10894827

Related topics

Quick answers

How many Periodontal Diseases clinical trials are recruiting right now?

38, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (7 trials), Spain (6 trials), Turkey (Türkiye) (6 trials), United Kingdom (3 trials), Switzerland (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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