Gingival Fluid Metabolomics in Periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional study collects gingival crevicular fluid from 60 adults (30 with periodontitis and 30 healthy controls) in a single visit. Targeted metabolomic analysis will identify differences between groups and explore how these differences relate to clinical periodontal measurements. Samples are processed with blinded grouping and strict handling to prevent contamination. The goal is to link metabolite profiles with disease status and clinical parameters. No intervention beyond standard periodontal assessment is involved.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 18 and 70 years.
2. Ability to understand the study procedures and provide written informed consent.
3. For the periodontitis group: diagnosis of periodontitis according to the 2018 classification of periodontal diseases.
4. For the healthy control group: periodontal health according to the 2018 classification, with no current diagnosis or history of periodontitis.

Exclusion Criteria:

1. Periodontal treatment during the previous 6 months.
2. Use of antibiotics, non-steroidal anti-inflammatory drugs, or immunosuppressive agents during the previous 6 months.
3. Pregnancy.

Where it's running

• AOU Policlinico G. Rodolico
  Catania, Italy, Italy Recruiting

Study contacts

• Study coordinator: Gaetano Isola
• Email: gaetano.isola@unict.it
• Phone: 0953785652

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.