How HIV and its treatment affect bone and tooth health
Intersection of Periodontitis with HIV-Antiretroviral Therapy-Induced Immune Reconstitution Bone Loss, on Alveolar Bone and Tooth Loss, in People Living with HIV
This study is looking at how HIV and the medications used to treat it can affect bone health in the jaw, which is important for keeping your teeth healthy, and it's aimed at helping people living with HIV understand and improve their oral health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11144466 on NIH RePORTER |
What this research studies
This research investigates the impact of HIV and antiretroviral therapy (ART) on bone health, particularly focusing on alveolar bone loss and tooth loss in people living with HIV. It aims to understand how the immune system's reactivation during ART contributes to bone density loss, especially in the jaw area, which is crucial for dental health. The study utilizes a mouse model to explore these effects and the relationship between periodontitis and HIV, given that individuals with HIV are at a higher risk for periodontal disease. By examining these interactions, the research seeks to identify potential interventions to mitigate bone loss and improve oral health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are undergoing antiretroviral therapy and may be experiencing or at risk for bone and tooth loss.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preserving bone and dental health in individuals living with HIV.
How similar studies have performed: Previous research has shown significant bone loss in HIV patients undergoing ART, indicating that this area of study is critical and has the potential for impactful findings.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Weitzmann, Mervyn Neale — Emory University
- Study coordinator: Weitzmann, Mervyn Neale
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.