Comparing five non-surgical gum treatments to lower systemic inflammation
Official title: Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols
Run by National and Kapodistrian University of Athens · NCT07077122 · Data updated 2026-11-12
This trial tests five different non-surgical periodontal treatments to see if they lower blood inflammation markers in adults with stage III or IV periodontitis.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | National and Kapodistrian University of Athens Academic / other |
| Locations | 1 site (Athens) |
| Status | Recruiting |
| Started | August 25, 2025 |
| Main results expected | July 15, 2027 |
| Study ends | December 15, 2027 |
| Registry record updated | September 4, 2025 |
| Trial ID | NCT07077122 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with stage III or IV periodontitis who are non-smokers or light smokers (<10 cigarettes/day), free of systemic diseases or medications that affect inflammatory markers, not pregnant or breastfeeding, and without recent antibiotics or periodontal treatment are ideal candidates.
✕Probably not a fit
People with mild periodontitis, heavy smokers, those taking medications or with systemic conditions that alter inflammatory markers, recent periodontal treatment, or pregnancy/lactation are unlikely to qualify or benefit from the specific outcomes measured.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized clinical trial compares five non-surgical periodontal protocols—including scaling and root planing, air polishing, adjunctive 810 nm diode laser, and antibiotic prophylaxis—to measure their effects on systemic inflammatory burden. Participants with advanced periodontitis will be randomly assigned to one of the treatment arms and undergo standardized mechanical debridement with or without the specified adjuncts. Blood samples will be collected at baseline and at follow-up visits to measure inflammatory biomarkers such as CRP and IL-6, and clinical periodontal outcomes and bacteremia will be monitored. The trial excludes heavy smokers, recent antibiotic or periodontal treatment recipients, pregnant or lactating people, and those on medications that alter inflammatory markers.
Why it matters
Potential benefit: If successful, the findings could identify treatment approaches that reduce systemic inflammation linked to periodontitis and help guide safer, more effective non-surgical care.
How similar studies have gone: Prior research shows non-surgical periodontal therapy can modestly reduce systemic inflammatory markers, but evidence for added benefit from antibiotics, lasers, or air polishing as systemic interventions is mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Periodontitis stage III or IV * Non-smokers or light smokers (\<10 cigarettes/day) * No NSAIDs in regular basis or antibiotics 3 months before * No previous periodontal treatment 12 months before * No presence of other acute or chronic infections * No systemic disease or medication known to affect the serum level of inflammatory markers (cyclooxygenase inhibitors, platelet aggregation inhibitors, lipid lowering agents, â-adrenoreceptor antagonists, angiotensin converting enzyme inhibitors, antidiabetic agents, estrogen-based medications, medication for autoimmune disease, magnesium or vitamin E supplements) * No pregnancy or lactation * Written informed consent.
Where it's running
-
Department of Periodontology, Dental School of Athens
Athens, Greece Recruiting
Study contacts
- Study coordinator: Zampa Evangelia
- Email: elina_zampa@windowslive.com
- Phone: 00306987027896
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
-
Association Between Periodontitis and Dry Eye Disease in Adults
This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.
-
Periodontal Infection and Inflammatory Markers in Missed Abortion
Researchers will test whether gum infection and inflammation are linked to missed abortion in pregnant women with no major chromosomal problems.
-
Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease
This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.
-
Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment
This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.
-
Boron, Oxidative Stress, and Inflammation in Periodontitis
This observational study compares boron levels and inflammation markers in saliva and gum tissue between people with periodontitis and healthy controls to see if boron relates to gum inflammation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.