Comparing five non-surgical gum treatments to lower systemic inflammation
Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols
This trial tests five different non-surgical periodontal treatments to see if they lower blood inflammation markers in adults with stage III or IV periodontitis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Sex | All |
| Sponsor | National and Kapodistrian University of Athens Academic / other |
| Locations | 1 site (Athens) |
| Trial ID | NCT07077122 on ClinicalTrials.gov |
What this trial studies
This randomized clinical trial compares five non-surgical periodontal protocols—including scaling and root planing, air polishing, adjunctive 810 nm diode laser, and antibiotic prophylaxis—to measure their effects on systemic inflammatory burden. Participants with advanced periodontitis will be randomly assigned to one of the treatment arms and undergo standardized mechanical debridement with or without the specified adjuncts. Blood samples will be collected at baseline and at follow-up visits to measure inflammatory biomarkers such as CRP and IL-6, and clinical periodontal outcomes and bacteremia will be monitored. The trial excludes heavy smokers, recent antibiotic or periodontal treatment recipients, pregnant or lactating people, and those on medications that alter inflammatory markers.
Who should consider this trial
Good fit: Adults with stage III or IV periodontitis who are non-smokers or light smokers (<10 cigarettes/day), free of systemic diseases or medications that affect inflammatory markers, not pregnant or breastfeeding, and without recent antibiotics or periodontal treatment are ideal candidates.
Not a fit: People with mild periodontitis, heavy smokers, those taking medications or with systemic conditions that alter inflammatory markers, recent periodontal treatment, or pregnancy/lactation are unlikely to qualify or benefit from the specific outcomes measured.
Why it matters
Potential benefit: If successful, the findings could identify treatment approaches that reduce systemic inflammation linked to periodontitis and help guide safer, more effective non-surgical care.
How similar studies have performed: Prior research shows non-surgical periodontal therapy can modestly reduce systemic inflammatory markers, but evidence for added benefit from antibiotics, lasers, or air polishing as systemic interventions is mixed.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Periodontitis stage III or IV * Non-smokers or light smokers (\<10 cigarettes/day) * No NSAIDs in regular basis or antibiotics 3 months before * No previous periodontal treatment 12 months before * No presence of other acute or chronic infections * No systemic disease or medication known to affect the serum level of inflammatory markers (cyclooxygenase inhibitors, platelet aggregation inhibitors, lipid lowering agents, â-adrenoreceptor antagonists, angiotensin converting enzyme inhibitors, antidiabetic agents, estrogen-based medications, medication for autoimmune disease, magnesium or vitamin E supplements) * No pregnancy or lactation * Written informed consent.
Where this trial is running
Athens
- Department of Periodontology, Dental School of Athens — Athens, Greece (Recruiting)
Study contacts
- Study coordinator: Zampa Evangelia
- Email: elina_zampa@windowslive.com
- Phone: 00306987027896
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.