A-PRF+ with Xenograft vs Collagen Membrane with Xenograft for Degree II Furcation Defects in Mandibular Molars

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares two regenerative approaches for mandibular molar degree II furcation involvements in adults with periodontitis. Participants undergo open flap debridement and receive either A-PRF+ mixed with Cerabone xenograft covered by an A-PRF+ membrane, or a xenograft covered by a resorbable collagen membrane. Outcomes include clinical periodontal healing, radiographic bone regeneration via CBCT, and patient-reported outcomes (pain and satisfaction) assessed over 6 months, along with changes in the TWEAK biomarker in gingival crevicular fluid. Baseline and 6-month follow-up measurements will include probing depths, attachment levels, recession, plaque and gingival indices, and CBCT-derived bone metrics.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 18 years old
* Patients diagnosed with periodontitis who have completed non-surgical treatment: scaling and root planing
* Patients attending a follow-up visit at least 5 weeks after non-surgical treatment, demonstrating compliance and good oral hygiene cooperation
* Presence of a mandibular molar with a Degree II furcation involvement according to Hamp (1975), presenting a residual periodontal pocket at the buccal site (PPD ≥ 5mm) after non-surgical treatment, and showing radiolucency in the furcation area on CBCT imaging
* Plaque Index (PlI) \< 1 following non-surgical treatment
* Width of keratinized gingiva ≥ 2mm
* Teeth with furcation defects where gingival recession does not extend apically beyond the buccal furcation fornix (no supragingival furcation exposure)
* Teeth without occlusal trauma, pulpal or periapical pathologies, and no combined periodontic-endodontic lesions
* Degree II furcation involvement according to Hamp (1975) and Subclass A or B according to Tarnow and Fletcher (1984)
* The defect is located apical to the interproximal alveolar bone crest on CBCT imaging

Exclusion Criteria:

* Patients with systemic diseases affecting periodontal treatment outcomes, such as: diabetes mellitus, heart disease requiring anticoagulant therapy, blood disorders, immunodeficiency, etc
* Pregnant or lactating patients
* Patients who have used antibiotics or any other medications affecting periodontal treatment outcomes within the last 6 months
* Patients who smoke tobacco.
* Patients who have used aspirin or medications affecting blood coagulation within 2 weeks prior to the blood collection for PRF preparation
* Patients with a history of allergy to local anesthetics
* Defects associated with grade II tooth mobility that has not been splinted, or grade III tooth mobility according to Miller (2014)

Where it's running

• Faculty of Dentistry, University of Medicine and Pharmacy at Ho Chi Minh City
  Ho Chi Minh City, Ho Chi Minh City (HCMC), Vietnam Recruiting

Study contacts

• Study coordinator: Thanh Si Ho, Doctor of Dental Surgery
• Email: sithanhlk2000@gmail.com
• Phone: +84944510521

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Mandibular molar furcation defects in advanced periodontitis: a regenerative treatment comparison

  In people with advanced gum disease, this study tests two regenerative treatments for Hamp Class II furcation defects in lower molars to see which works better and whether CBCT imaging matches what clinicians find during surgery.

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• Association Between Periodontitis and Dry Eye Disease in Adults

  This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.

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• Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease

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  Recruiting Abant Izzet Baysal University · Bolu, Central · NCT07826728

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.