Investigating gene and microbiome profiles in gum diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the transcriptomic and microbiomic profiles associated with periodontitis and peri-implantitis. Patients aged 18 and older with defined cases of these conditions will undergo a thorough examination, including tissue biopsies from affected sites. The study will assess gene expression and microbiome characteristics to better understand the underlying mechanisms of these diseases. The findings could lead to improved diagnostic and therapeutic strategies for managing periodontal and peri-implant diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

≥18 years of age Defined periodontitis at two non-adjacent teeth Defined peri-implantitis at ≥1 implant Signed informed consent

Exclusion Criteria:

Surgical intervention of periodontitis and/or peri-implantitis during last 6 months.

Local or systemic use of antibiotics during last 6 months.

Where it's running

• Aqua Dental Specialistklinik
  Stockholm, Sweden Recruiting

Study contacts

• Principal investigator: Tülay Lindberg, Ass.prof — Karolinska Institutet
• Study coordinator: Carl Titusson, DDS, MSc
• Email: carl.titusson@ki.se
• Phone: +4685088126

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Minimally invasive non-surgical treatment for peri-implantitis

  This test compares a gentler, minimally invasive non-surgical cleaning (MINST) with standard non-surgical cleaning for adults who have peri-implantitis to see which gives better gum, bone, and patient-reported outcomes over 12 months.

  Recruiting St. Anne's University Hospital Brno, Czech Republic · Brno · NCT07466966

• Understanding the links between periodontitis, inflammation, and diabetes

  This study is trying to understand how periodontitis and inflammation are connected to diabetes by looking at biological samples from patients with severe gum disease and healthy people.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Ivry-sur-Seine and 1 other locations · NCT04831060

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• Association Between Periodontitis and Dry Eye Disease in Adults

  This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.

  Recruiting University of Sulaimani · Sulaymaniyah, As Sulaymaniyah Governorate · NCT07873697

• Periodontal Infection and Inflammatory Markers in Missed Abortion

  Researchers will test whether gum infection and inflammation are linked to missed abortion in pregnant women with no major chromosomal problems.

  Recruiting Necmettin Erbakan University · Konya, Konya · NCT07864220

• Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease

  This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.

  Recruiting Abant Izzet Baysal University · Bolu, Central · NCT07826728

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.