Non-surgical gum treatment effects on saliva markers in smokers and non-smokers with periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This non-randomized comparative study enrolls 44 systemically healthy adults with Stage II or III periodontitis, split into 22 current smokers and 22 non-smokers. Participants provide unstimulated whole saliva and undergo a full-mouth clinical exam at baseline, receive standardized non-surgical periodontal therapy (scaling and root planing), and return for repeat saliva collection and clinical measurements six weeks later. The study measures salivary levels of Dkk-1, sclerostin (SOST), and PLAP-1 alongside standard periodontal clinical parameters to track biological and clinical changes. The goal is to compare biomarker and clinical responses to therapy between smokers and non-smokers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Systemically healthy.
* Diagnosed with Stage II and III periodontitis.
* Presence of ≥ 20 teeth (excluding third molars).
* Current smoker OR non-smoker

Exclusion Criteria:

* Presence of systemic diseases affecting the periodontium.
* Use of medications affecting inflammation.
* Received periodontal therapy in the past 6 months.
* Received antibiotic therapy in the last 3 months.
* Alcohol use.

Where it's running

• Al-Sadr Specialized Dental Center
  Baghdad, Baghdad Governorate, Iraq Recruiting
• Sadr Specialized Dental Center
  Baghdad, Baghdad Governorate, Iraq Recruiting

Study contacts

• Principal investigator: Hussein Abdul-Rassul Hatiem, B.D.S., M.Sc. Student — College of Dentistry / Mustansiriyah University
• Study coordinator: Hussein Abdul-Rassul Hatiem, B.D.S., M.Sc. Student
• Email: husseinabdulrassol@uomustansiriyah.edu.iq
• Phone: +9647703916382

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.