Treatment for gum disease to slow heart valve narrowing
Official title: Intensive Treatment on Periodontitis in Aortic Stenosis
Run by China National Center for Cardiovascular Diseases · NCT06587971 · Data updated 2026-11-12
This study is testing if treating gum disease can help slow down the worsening of heart valve narrowing in adults who have both aortic valve stenosis and gum issues.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 920 (estimated) |
| Sponsor | China National Center for Cardiovascular Diseases Government |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | May 10, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 2027 |
| Registry record updated | September 19, 2024 |
| Trial ID | NCT06587971 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 years or older with moderate aortic valve stenosis and mild-to-moderate periodontitis.
✕Probably not a fit
Patients with end-stage renal disease, those who are pregnant or breastfeeding, or individuals unable to adhere to the treatment protocol may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to determine whether standardized periodontal therapy can slow the progression of aortic valve stenosis in adults with moderate aortic valve stenosis and coexisting gingivitis or mild-to-moderate periodontitis. Participants will be screened for eligibility based on their aortic valve peak velocity and periodontal status, and then randomly assigned to either receive comprehensive periodontal therapy or only oral hygiene education. The study seeks to answer if chronic periodontitis is an independent risk factor for the accelerated progression of aortic valve stenosis.
Why it matters
Potential benefit: If successful, this treatment could potentially slow the progression of aortic valve stenosis in patients with periodontal disease.
How similar studies have gone: There is limited information on similar studies, making this approach relatively novel and untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 years or older. * Aortic valve peak velocity (Vmax) between 3.0 and 3.9 m/s. * Diagnosis of aortic valve stenosis identified as degenerative aortic valve stenosis. * Presence of gingivitis or mild-to-moderate periodontitis confirmed by periodontal probing or panoramic dental radiography. * Willingness to participate in the study and signing of informed consent. Exclusion Criteria: * End-stage renal disease with eGFR \< 15 ml/min/1.73m² (according to the Cockcroft \& Gault formula). * Pregnant, breastfeeding, and women of childbearing age (except those with effective contraception). * Factors that may affect study follow-up or adherence to periodontal therapy. * Patients unwilling or unable to undergo comprehensive periodontal treatment. * Patients who do not consent to participate in the study.
Where it's running
-
China National Center for Cardiovascular Diseases
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Principal investigator: Erli Zhang, MD, PhD — China National Center for Cardiovascular Diseases
- Study coordinator: Erli Zhang, MD, PhD
- Email: aricho1985@163.com
- Phone: +86-18500853301
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Transcatheter Aortic Valve Replacement Registry for Outcomes and Quality Monitoring
This registry collects information from hospitals about patients undergoing TAVR to see how care and outcomes compare to guidelines and nationwide data.
-
High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
-
Association Between Periodontitis and Dry Eye Disease in Adults
This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.
-
Periodontal Infection and Inflammatory Markers in Missed Abortion
Researchers will test whether gum infection and inflammation are linked to missed abortion in pregnant women with no major chromosomal problems.
-
Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease
This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.
-
Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment
This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.