Periodontal status, smoking, and salivary inflammasome markers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares salivary inflammasome and cytokine levels across four groups: smokers with periodontitis, non-smokers with periodontitis, smokers without periodontitis, and non-smokers without periodontitis. Participants receive medical and dental history review, full intraoral and periodontal examinations according to the 2017 AAP/EFP classification, and unstimulated saliva collection prior to clinical measurements. Saliva samples are stored at −80°C and later analyzed by ELISA to quantify NLRP-3, NLRP-6, NLRP-12, NLRC-5, IL-1β and IL-10. The study aims to determine whether these salivary markers can serve as noninvasive diagnostic indicators of periodontitis and whether smoking modulates their associations with periodontal status.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* systemically healthy,
* clinical diagnosis of periodontitis,
* clinical diagnosis of periodontal health

Exclusion Criteria:

* history of regular use of systemic antibiotics, anti-inflammatory, or antioxidant drugs (previous 6 months);
* nonsurgical periodontal treatment (previous 6 months);
* surgical periodontal treatment (previous 12 months);
* presence of \<20 teeth;
* current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy);
* diabetes diagnosis; rheumatoid arthritis diagnosis; and pregnancy, lactating, or excessive alcohol consumption.

Where it's running

• Uskudar University, Faculty of Dentistry
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Kubra KARADURAN — Uskudar University
• Study coordinator: Kubra KARADURAN
• Email: kubra95krdrn@gmail.com
• Phone: +905395913683

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.