How bacteria beneath the gums change after resective, regenerative, or peri-implant surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with periodontitis or peri-implantitis will receive the surgical treatment indicated for their condition (resective periodontal, regenerative periodontal, or peri-implantitis surgery). Subgingival plaque and saliva samples will be collected at baseline and at defined postoperative follow-ups. Microbiome composition will be analyzed using next-generation sequencing and summarized with the Subgingival Microbial Dysbiosis Index (SMDI). The study aims to characterize microbial shifts after each procedure and determine whether surgical type influences recovery or disruption of the subgingival ecosystem.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Confirmed diagnosis of Peri-implantitis (for the peri-implantitis surgery arm), or Stage III/IV periodontitis (for the periodontal surgery arms)
* Indication for surgical therapy corresponding to the assigned study arm
* Ability to understand the study procedures and provide written informed consent
* Adequate oral hygiene (API/SBI according to the clinician's judgment)
* Willingness and ability to attend all follow-up visits
* Willingness to provide salivary and subgingival plaque samples for microbiome analyses (NGS, SMDI)

Exclusion Criteria:

* Systemic conditions contraindicating oral surgical procedures
* Severe systemic diseases (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders)
* Use of systemic antibiotics within the previous 3 months
* Active COVID-19 infection at the time of surgery
* Pregnancy or breastfeeding
* Drug or alcohol abuse
* Smoking more than 10 cigarettes per day
* Known allergies to materials used in the assigned intervention (e.g., local anesthetics, sutures, membranes, bone grafting materials)
* Participation in another clinical study within the previous 30 days
* Acute oral infections that contraindicate participation
* Inability or unwillingness to comply with all follow-up appointments Lack of capacity to provide informed consent

Where it's running

• University Hospital Münster
  Münster, North Rhine-Westphalia, Germany Recruiting

Study contacts

• Principal investigator: Benjamin Ehmke, Univ. Prof. Dr. med. dent. — Clinic for Periodontology and Conservative Dentistry, University of Münster
• Study coordinator: Benjamin Ehmke, Univ. -Prof. Dr. med. dent.
• Email: ehmke@uni-muenster.de
• Phone: +4902518347059

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.