Guided biofilm therapy's effect on gum tissue biomarkers in periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

All participants will receive the same toothpaste, toothbrush, interdental aids, and brushing instructions, and baseline full-mouth periodontal charting and radiographs will be obtained. Gingival crevicular fluid (GCF) samples will be collected at baseline and one hour later from sites allocated to either guided biofilm therapy (GBT) or control procedures. Control sites receive supragingival ultrasonic debridement initially and root surface debridement (RSD) after one week, while test sites receive the GBT protocol as the alternative non-surgical intervention. Clinical outcomes and epithelial–mesenchymal biomarkers in GCF will be compared between groups to see if GBT produces different biochemical and clinical changes than conventional care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult subjects (\>18 years).
2. Subjects are not currently under active periodontal therapy or joining other trial in the last 3 months.
3. Patients must be diagnosed with generalized unstable periodontitis with bilateral, symmetrical distribution of PPD ≥ 4mm and positive BOP.

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Exclusion Criteria:

1. Patients not diagnosed with periodontitis.
2. Patients consuming antibiotics.
3. Regular users of nonsteroidal anti-inflammatory drugs (NSAIDs).
4. Patients receiving periodontal treatment 3-months prior to the study.
5. Pregnant or mothers in a breastfeeding period.
6. Third molars and teeth with furcation involvement.
7. Patients taking antioxidant supplements.
8. Patients with heavy calculus that would prevent PerioPaper strips entrance to the periodontal pocket.
9. Patient with pulmonary diseases and with a history of allergy to erythritol.
10. Patients not willing to participate. -

Where it's running

• College of Dentistry, University of Baghdad
  Baghdad, Iraq Recruiting

Study contacts

• Study coordinator: Ibrahim Haider Sadeq, B.D.S
• Email: Ibrahim.Ata2405@codental.uobaghdad.edu.iq
• Phone: 009647722247642

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.