Using a bone substitute material to treat furcation defects in molars

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of a bone substitute material in the surgical treatment of degree II furcation defects in molars. It involves 200 patients who will be randomly assigned to receive either standard open-flap debridement or the same procedure with the addition of a bone substitute material. The primary outcome is the closure of the furcation defect, while secondary outcomes include various clinical measurements and patient-reported outcomes. The study will follow participants for up to 10 years to assess long-term effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients should present with at least one surgically accessible molar (in tooth position 6 or 7) diagnosed with a single furcation defect degree II (at any aspect).

Following initial periodontal therapy, teeth to be included should present with one site with furcation defect degree II in combination with:

* Bleeding on probing
* Probing pocket depth of ≥6 mm
* Soft tissue coverage of the furcation entrance Patients should present with a full mouth plaque score ≤25%.

Exclusion Criteria:

* Multiple deep furcation defects (degree II - III) at the same tooth
* Vertical attachment loss \>50% at aspects not facing the furcation defect
* Defects presenting with apico-marginal communication
* Intake of systemic antibiotics within 6 months
* Systemic conditions/medication impeding surgical intervention (e.g. uncontrolled diabetes, immunosuppressive medication)

Where it's running

• Department of Periodontology, Institute of Odontology
  Gothenburg, Sweden Recruiting

Study contacts

• Study coordinator: Jan Derks, PhD
• Email: jan.derks@odontologi.gu.se
• Phone: +46766183124‬

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.