Condition

Smoking clinical trials and research

• 45Clinical trials
• 267NIH research projects
• 2New in 30 days
• 12Countries

Newest Smoking clinical trials

All recruiting trials (45)

• Salivary IL-8 and Serum IL-6 as Biomarkers to Distinguish Oral Premalignant Disorders in Smokers and Never-Smokers

  This study tests whether salivary IL-8 and blood IL-6 can help tell apart adults with oral premalignant conditions from those with healthy mouths, and whether smoking influences these markers.

  Recruiting British University In Egypt · Cairo · NCT07915570

• Access to multiple tobacco flavors to help adult cigarette smokers quit using e-cigarettes

  This study tests whether giving adult smokers an e-cigarette with a choice of flavors helps them quit smoking by the end of 13 weeks.

  Recruiting at 5 sites RAI Services Company · Fort Lauderdale, Florida and 4 other locations · NCT07879638

• Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease

  This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.

  Recruiting Abant Izzet Baysal University · Bolu, Central · NCT07826728

• Heated tobacco access and cigarette quitting among adult smokers

  This study tests whether giving adult smokers access to a heated tobacco product helps them quit smoking by the end of 3 months.

  Recruiting at 9 sites RAI Services Company · Brandon, Florida and 8 other locations · NCT07710820

• How flavors of ENDS might help adults quit smoking their usual cigarettes

  This study tests whether giving adults who smoke their regular cigarettes an electronic nicotine delivery system with different flavors can help them quit smoking their usual cigarettes after 3 months.

  Recruiting at 7 sites RAI Services Company · Maitland, Florida and 6 other locations · NCT07598136

• Comparing chest PNF and chest mobility exercises for university students who smoke

  This trial tries two chest exercise programs to see if they help 18–24-year-old university students who smoke breathe better and improve lung function.

  Recruiting University of Yalova · Yalova, Yalova · NCT07488741

• Periodontal status, smoking, and salivary inflammasome markers

  This trial will test whether levels of salivary inflammasome proteins (NLRP-3, NLRP-6, NLRP-12, NLRC-5, IL-1β and IL-10) differ between people with and without periodontitis and whether smoking changes those levels.

  Recruiting Uskudar University · Istanbul · NCT07312552

• Brenipatide to help adults who recently quit smoking avoid relapse

  This trial will see if brenipatide helps adults who recently quit smoking stay off cigarettes better than a placebo.

  Recruiting at 28 sites Phase 2 Eli Lilly and Company · Rogers, Arkansas and 28 other locations · NCT07223840

• Personalized treatment to help people with cancer quit smoking and live longer

  We will test whether personalized tobacco treatment using clinical, genetic, and biomarker information helps cancer patients who smoke quit and use cessation medications more than usual care.

  Recruiting at 2 sites Washington University School of Medicine · St Louis, Missouri and 1 other locations · NCT07166120

• Abuse potential of five modern oral nicotine products

  This will test how five modern oral nicotine products compare with cigarettes and nicotine gum in how satisfying they feel and how much nicotine adult smokers absorb.

  Recruiting RAI Services Company · Overland Park, Kansas · NCT07132814

• Mapping smoking environments with smartphone photos and AI to help people quit

  This project will see if smartphone photos, sensors, and AI can identify places and situations that trigger smoking for daily smokers who plan to quit and are using nicotine patches.

  Recruiting Phase 4 Duke University · Durham, North Carolina · NCT07089901

• Collecting biospecimens and health data from people having low-dose CT lung screening

  This project will collect blood, urine, tissue, imaging, and questionnaire data from people getting LDCT lung screening to try to improve how well we predict who will develop lung cancer.

  Recruiting at 2 sites Chung Shan Medical University · Taichung, Taiwan and 1 other locations · NCT07048236

• Personalized brain treatments for smokers using rTMS

  This study is testing if personalized brain treatments using rTMS can help smokers reduce their nicotine cravings by looking at how their brains respond to emotions.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06991062

• Inspire HER: a heart-health and stress-support program for Black women

  This project will test whether the Inspire HER lifestyle program helps Black women with higher heart disease risk improve heart health and manage stress.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06966258

• Using wearable devices to improve health in high-risk stroke patients

  This study is testing if smart wearable devices can help high-risk stroke patients manage their health better by reminding them to take medication, monitor their heart rate, and encourage exercise.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT06935513

• Combining acupuncture, acupressure, and nicotine therapy to help quit smoking

  This study is testing if a mix of acupuncture, acupressure, and nicotine therapy can help people quit smoking better than just using nicotine therapy alone.

  Recruiting The University of Hong Kong · Hong Kong · NCT06931054

• Actívatexto: Helping Latinos quit smoking and become more active

  This trial tests whether Actívatexto, a text-message program combined with wearables and nicotine replacement, helps Latino adults who smoke quit and increase their physical activity.

  Recruiting University of Rochester · Rochester, New York · NCT06926608

• Reducing tobacco use in people living with HIV in Switzerland

  This study is testing if using e-cigarettes and nicotine pouches can help people living with HIV quit smoking for a week after six months.

  Recruiting at 6 sites University Hospital, Basel, Switzerland · Basel, Basel and 6 other locations · NCT06789692

• Technology-based motivational interviewing to help adults quit smoking

  This project will try a chatbot-based motivational interviewing coach to help adult primary care patients who smoke become ready to quit and create a personalized quit plan.

  Recruiting at 2 sites University of California, San Francisco · San Francisco, California and 1 other locations · NCT06713603

• Using an air quality monitor to encourage smoke-free homes for cancer patients

  This study is testing if using an air quality monitor can help cancer patients who smoke create smoke-free homes and quit smoking.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT06693700

• Proactive tobacco treatment for household smokers through pediatric care

  This study is testing a new way to help household smokers quit tobacco by using support from pediatric care to see if it can improve their chances of success.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06582693

• Online DBT-informed skills program to help adult smokers quit and manage distress

  This program will try an online DBT-informed skills course to help adult smokers quit or cut down and feel less psychological distress.

  Recruiting Chinese University of Hong Kong · Tai Po, New Territories and 1 other locations · NCT06575673

• Impact of Centrifuge Speed on Saliva Protein Levels in Smokers

  This study tests how different speeds of a machine that spins saliva samples can change the levels of a specific protein in the saliva of smokers and non-smokers to better understand the effects of smoking on oral health.

  Recruiting Izmir Katip Celebi University · Izmir, Çiğli · NCT06561971

• Comparing mobile health screening to traditional methods for early detection of oral cancer in rural Varanasi.

  This study tests if using mobile health screenings can help find oral cancer earlier than traditional methods for people living in rural Varanasi.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT06535867

• A program to help cancer patients quit smoking

  This study is testing a special program to help recent cancer patients quit smoking by giving them personalized support based on their type of cancer.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06484179

• Pain and Smoking: A Program to Help Veterans Quit Smoking with Chronic Pain

  This study tests whether the PASS2 program, which adds nightly surveys to a pain-and-smoking cessation intervention, helps Veterans with chronic pain quit smoking better than usual care.

  Recruiting VA Office of Research and Development · West Haven, Connecticut · NCT06442514

• Mobile health outreach for men's cancer screening

  This study is testing a mobile health service that brings cancer screening directly to men at their workplaces, especially those in high-risk groups, to help them get checked for prostate cancer and other urological issues.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT06357416

• Using magnetic stimulation to help people quit smoking

  This study is testing if a new type of brain stimulation can help daily smokers quit smoking by making it easier for them to stop.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06346028

• Evaluating how flavor affects smokers switching to e-cigarettes

  This study tests whether different e-cigarette flavors can help smokers switch from regular cigarettes to e-cigarettes more easily.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06264154

• Comparing e-cigarettes and nicotine pouches for reducing cigarette smoking

  This study is testing whether e-cigarettes or nicotine pouches help adult smokers cut down on their cigarette use over four weeks.

  Recruiting Yale University · New Haven, Connecticut · NCT06077240

• Investigating the impact of a tobacco heating system on healing of lower limb fractures in smokers

  This study is testing if switching from regular cigarettes to a tobacco heating system helps smokers heal better from lower limb fractures.

  Recruiting University Hospital Tuebingen · Tübingen, Baden-Wurttemberg · NCT05859451

• Personalized treatment for smoking cessation in primary care

  This study is testing a personalized approach to help people quit smoking in primary care to see if it works better than the usual methods.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05846841

• Using kava to help people quit smoking and manage stress and sleep issues

  This study is testing if taking kava can help people who smoke quit smoking while also reducing stress and improving sleep.

  Recruiting Phase 2 University of Florida · Gainesville, Florida · NCT05814055

• A program to help rural smokers who aren't ready to quit

  This study is testing a new program to help rural adults who smoke but aren't ready to quit by providing them with support and resources through mobile health technology and community paramedics.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT05790486

• Using community pharmacists to help rural smokers quit

  This study is testing a new program where pharmacists help rural smokers in Appalachia quit smoking by providing medication and support, like texting and quitline resources.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05660525

• Helping smokers with cancer quit using self-determination and messaging

  This study is testing if a new way of helping smokers with cancer quit by letting them choose their own quit plan and providing support through instant messaging can be more effective than other methods.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT05643469

• Understanding brain activity related to smoking lapses

  This study is trying to see how brain activity changes in adults who smoke right before they might slip up and have a cigarette after trying to quit.

  Recruiting Penn State University · University Park, Pennsylvania · NCT05572671

• Research on lung cancer screening behaviors and outcomes in high-risk individuals in Taiwan

  This study looks at how high-risk individuals in Taiwan, like smokers or those with a family history of lung cancer, are getting screened for lung cancer using low-dose CT scans to see how effective these screenings are.

  Recruiting at 5 sites Chung Shan Medical University · Taichung, Taiwan and 6 other locations · NCT05557487

• Evaluating lung cancer screening with CT scans in smokers

  This study is testing if low-dose chest CT scans can help find lung cancer early in current or former smokers aged 50 to 80.

  Recruiting Hospital St. Joseph, Marseille, France · Marseille · NCT05486455

• Combining financial coaching with smoking cessation support

  This study is testing whether combining financial coaching with smoking cessation support helps low-income smokers quit smoking better than just standard counseling alone.

  Recruiting Phase 3 NYU Langone Health · New York, New York · NCT05154669

• Preventing postpartum smoking relapse with hormone treatment

  This study is testing if progesterone can help new and expecting moms who smoke stay smoke-free after giving birth.

  Recruiting Phase 4 University of Minnesota · Minneapolis, Minnesota · NCT04783857

• Lung macrophage patterns in COPD-susceptible smokers

  This study tests whether lung macrophage features differ in smokers who may be at risk for COPD, by comparing people with and without air trapping but with preserved lung function.

  Recruiting University of California, San Francisco · San Francisco, California and 2 other locations · NCT04722835

• How a substance affects brain activity and smoking urges in young nondaily smokers

  The study will test whether giving a specific substance changes brain activity, cigarette/e-cigarette craving, and impulsive choices in young adults who smoke on some days.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT04281979

• Collecting biological samples from individuals with and without lung disease

  This study is collecting blood, urine, and airway samples from both healthy people and those with lung diseases to see how their biology differs and learn more about these conditions.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT01776398

• Using Emotional Freedom Techniques to help smokers quit

  This study is testing if Emotional Freedom Techniques can help smokers with anxiety and cravings quit smoking better when combined with therapy.

  Recruiting Early Phase 1 Soul Medicine Institute · Ormskirk, Lancashire · NCT00981396

NIH-funded research (newest 40 of 267)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Blood-based markers to identify lung cancer risk in never-smokers

  A researchers team at NYU School of Medicine is testing blood tests that might flag higher lung cancer risk in people who have never smoked, helping decide who might need screening.

  NIH research New York University School of Medicine · New York, United States · NIH-11623223

• Social stress and smoking: why disadvantaged young adults struggle to quit

  This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11540695

• BSMART: A program to help people with HIV quit smoking

  A program in HIV care settings tests a proven plan to help people with HIV quit smoking, using quick counseling and a switch to quitting medications.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11535386

• BSMAT: Helping people with HIV quit smoking through routine support

  A HIV care program in Botswana aims to help people living with HIV quit smoking using a proven 5A brief intervention plus support medication.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11535385

• Improving treatment for people with HIV who smoke and drink in Nairobi, Kenya

  A study tests a new plan to help people with HIV in Nairobi quit smoking and reduce heavy drinking, using a low-cost medicine and counseling.

  NIH research University of Chicago · Chicago, United States · NIH-11535379

• I-STOP: a mobile health program to help people with HIV quit smoking

  A smartphone-based program designed to help people with HIV quit smoking in a sustainable, affordable way.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11535367

• Smoking cessation help for people with HIV in South Africa

  A program is being tested to help people living with HIV in South Africa quit smoking in ways that fit low-resource clinics and show good value.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11535332

• Mobile tools to understand how sleep affects quitting smoking

  This project uses a smartphone to track sleep and smoking in lower-income adults trying to quit to find how sleep patterns relate to staying smoke-free.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11502972

• Integrated approach to lung screening and quitting for African Americans

  A multi-level program aims to boost LDCT lung cancer screening uptake and help African American smokers quit, with support from a comprehensive community-focused plan.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11491488

• Using pragmatic rollout strategies to connect Salvation Army clients with evidence-based quitting help

  This grant tests new ways to help Salvation Army clients who smoke get free, proven help to quit and lower cancer risk.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11457461

• Cancer risk and quitting in real life: how our surroundings shape smoking behavior

  This project studies how everyday surroundings and mobile-phone data influence cravings and quitting smoking to reduce cancer risk.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11450335

• Peer-led smoking-cessation program for public housing residents

  A peer-led program with eight group sessions plus nicotine replacement therapy is tested on adults living in public housing to help them quit smoking.

  NIH research George Washington University · Washington, United States · NIH-11449312

• Real-world use of quit aids in US adults

  This project studies how well different quitting aids work in everyday life for adults in the United States who smoke.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11447909

• Smoking and blood vessel health linked to brain aging in adults

  This project looks at how smoking and quitting affect tiny and large blood vessels in the brain and body, and how these changes relate to brain aging and dementia risk.

  NIH research Vassar College · Poughkeepsie, United States · NIH-11440357

• A new approach to help adults who aren’t ready to quit start quitting more often

  A health intervention uses tailored daily messages to motivate and support adults who aren’t ready to quit smoking, helping them make quit attempts and stay abstinent.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11432918

• Very low nicotine cigarettes to help quitting for people with chronic back pain

  A study will test whether switching to very low nicotine cigarettes helps people with chronic back pain quit smoking and feel less pain.

  NIH research Duke University · Durham, United States · NIH-11430727

• Flavor rules and youth smoking/vaping: what happens when flavors are restricted

  A nationwide study will look at how banning or limiting flavored tobacco products affects how often adults and youth smoke or vape.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11421858

• Modeling how new tobacco products may affect smoking and health over time

  A long-running NIH grant from the University of Michigan aims to predict how cigarettes, cigars, and newer products like e-cigarettes could change future smoking patterns and health outcomes.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11421839

• Exercise-based quitting aid for adults with high anxiety sensitivity

  A program tests whether a structured, high‑intensity exercise plan helps adults with high anxiety sensitivity quit smoking and feel better mentally.

  NIH research University of Texas at Austin · Austin, United States · NIH-11419742

• Smoking cessation support for people with HIV in South Africa

  A Johns Hopkins-led effort tests practical, proven smoking-cessation approaches with people living with HIV in South Africa to see if they work well in that setting and are worth expanding.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11419226

• How Smoking Affects the Rotator Cuff Tendon-Bone Attachment

  This project studies how cigarette smoking changes the healing and strength of the tendon–bone connection in the shoulder after injury, using a smoking chamber and rat models.

  NIH research Clemson University · Clemson, United States · NIH-11413732

• Sustainable mobile health support to help people with HIV quit smoking

  Researchers are testing a scalable smartphone-based program to help people with HIV quit smoking in real-world care settings.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11411242

• Understanding why lung cancer risk from smoking differs among populations

  This grant looks at why people from different groups have different lung cancer risks from cigarette smoking and what genetic and biochemistry clues explain those differences.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11411158

• A new, phone-based olfactory aid to help adults quit smoking

  A smartphone-based program will combine a guided olfactory cue with a popular quit-smoking app to help adults reduce cravings and support cessation.

  NIH research University of Houston · Houston, United States · NIH-11404970

• Understanding how the word natural on cigarillo packaging affects smokers and non-smokers

  This project studies how labeling cigarillos as “natural” influences people’s expectations, feelings, and use patterns.

  NIH research University of Nevada Reno · Reno, United States · NIH-11402607

• Multi-omic insights into alcohol use disorder with and without smoking

  A scientist team will study how DNA methylation and RNA patterns in brain tissue differ in people with alcohol use disorder, comparing those who smoke to those who don’t, to understand biology and potential drug targets.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11402206

• BSMART: HIV care-integrated smoking cessation program

  A program to help people living with HIV quit smoking using a proven 5A brief intervention plus support and medication within HIV clinics.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11401178

• Better ways to help people with HIV in Kenya quit smoking and reduce drinking

  This grant tests a plan to help people living with HIV in Nairobi quit smoking and cut back on alcohol by using cytisine and counseling.

  NIH research University of Chicago · Chicago, United States · NIH-11400982

• Amplifying menthol-cigarette ban effects with a quit-smoking campaign for menthol smokers

  A large study tests whether adding quit-smoking messages to a menthol-flavor ban can help menthol cigarette smokers quit rather than switch to other cigarettes.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11400541

• Actify: a mobile tool to help people quit smoking by managing mood

  A mobile app called Actify! helps people quit smoking by addressing depressive mood as part of the quit plan.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11400405

• Mobile health program to help people with HIV in Laos quit smoking

  This project offers a smartphone app plus clinic outreach to help people living with HIV in Laos quit smoking.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11400256

• Promoting Breastfeeding to Prevent Postpartum Smoking Relapse

  A trial tests whether encouraging new mothers to breastfeed helps prevent them from starting to smoke again after giving birth.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11400074

• Digital craving-regulation training to help adults quit smoking

  A brief, online program teaches adults how to manage cigarette craving to improve quitting with or without medication.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11399806

• Proactive smoking-cessation support in primary care via an automated e-visit

  A researcher team at a medical center is testing an electronic, auto-delivered quit-smoking visit in primary care to help adult smokers use evidence-based treatments.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11399022

• Harm-reduction sampling to help people not ready to quit smoking

  A practical approach tests whether giving people who aren’t ready to quit access to harm-reduction smoking aids can help them move toward quitting.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11397774

• Transforming smoking cessation care in cancer treatment

  A cancer center project helps doctors reliably help patients quit smoking during cancer care using electronic health records and proven quitting strategies.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11397545

• Novel mobile tool to help people ambivalent about quitting smoking

  A smartphone app trial helps adults who aren’t ready to quit smoking to engage with proven cessation support and move toward quitting.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11396514

• Culturally tailored smoking-cessation resources for American Indian people

  A randomized study tests culturally tailored digital smoking-cessation tools designed for American Indian individuals to help them quit smoking.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11395454

• Effects of e-cigarettes, nicotine pouches, menthol and nicotine on adults’ smoking and addiction

  This grant tests how different non-cigarette products and their ingredients affect smoking behavior in adults who currently smoke.

  NIH research Yale University · New Haven, United States · NIH-11394369

• Vitamin C in Pregnancy to Protect Kids’ Lungs from Smoking Effects

  A pregnancy vitamin C trial tests whether supplementing smoking mothers with vitamin C can improve kids’ lung function and reduce wheeze as they grow.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11394272

Related topics

Quick answers

How many Smoking clinical trials are recruiting right now?

45, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (28 trials), Turkey (Türkiye) (4 trials), Hong Kong (3 trials), China (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 2: 2, Early Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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