Hyaluronic Acid Added to Gum Therapy for Smokers with Periodontal Disease
Official title: The Effect of Adjunctive Use of Hyaluronic Acid in Non-Surgical Periodontal Treatment in Smoking Patients
Run by Marmara University · NCT07597213 · Data updated 2026-11-12
This study tests whether applying hyaluronic acid gel after non-surgical gum cleaning helps smokers with periodontitis heal better than cleaning alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 23 (estimated) |
| Sponsor | Marmara University Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | July 13, 2026 |
| Main results expected | July 2028 |
| Study ends | July 2028 |
| Registry record updated | August 18, 2026 |
| Trial ID | NCT07597213 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are smokers with Stage III–IV periodontitis, at least 20 natural teeth, and two non-adjacent interproximal sites per quadrant with PD and CAL ≥6 mm.
✕Probably not a fit
Patients without smoking history or without eligible periodontal sites may not benefit as much, and non-responders to NSPT could see limited improvement.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this split-mouth trial, smokers with periodontitis will receive non-surgical periodontal therapy (NSPT) and have test sites in one jaw treated with hyaluronic acid gel while other sites are not. The study will compare clinical outcomes, oxidative stress markers, and bacterial levels between the HA-treated sites and control sites over follow-up. Researchers will collect gingival fluid and subgingival bacteria samples to assess biochemical and microbiological changes. The trial aims to determine if HA provides additional clinical and molecular benefits after NSPT.
Why it matters
Potential benefit: If successful, HA adjunctive treatment could improve healing and reduce harmful bacteria and oxidative stress in smokers with periodontitis.
How similar studies have gone: Previous work in non-smokers has shown promise for HA as an adjunct in periodontal therapy; results in smokers require direct validation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Individuals who sign the informed consent form 2. Participants who are systemically healthy 3. Participants who smoke (for \>5 years and ≥10 cigarettes per day) 4. Participants diagnosed with Stage III or Stage IV periodontitis 5. Participants with at least 20 natural teeth present in the mouth (excluding third molars) 6. Participants with two non-adjacent interproximal sites in each quadrant of either jaw, presenting probing depth (PD) and clinical attachment level (CAL) ≥6 mm, and with no caries, restorations, or furcation involvement Exclusion Criteria: 1. Individuals who do not sign the informed consent form 2. Individuals having any systemic disease 3. Participants who have used antibiotics within the last 3 months 4. Participants who have received any periodontal treatment within 6 months prior to the study 5. Participants who are pregnant or lactating
Where it's running
-
Department of Periodontology, Faculty of Dentistry, Marmara University
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Basak Dogan
- Email: basakdogan@marmara.edu.tr
- Phone: +905332621170
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Diabetes, Dementia, and Oxidative Stress: A look at Nox2-related markers
This study tests whether oxidative stress linked to Nox2 is related to dementia risk in adults with type 2 diabetes.
-
Improved Facial Skin Quality After VYC-12L for Breast Cancer Survivors
This study tests whether intradermal injections of VYC-12L can improve facial skin quality and quality of life in adults who have completed breast cancer treatment.
-
High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
-
Association Between Periodontitis and Dry Eye Disease in Adults
This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.
-
Periodontal Infection and Inflammatory Markers in Missed Abortion
Researchers will test whether gum infection and inflammation are linked to missed abortion in pregnant women with no major chromosomal problems.
-
Opioid-Free vs Opioid-Based Anesthesia for Thyroid Surgery
This study tests whether a non-opioid anesthesia approach can match or improve outcomes for adults undergoing thyroidectomy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.