Diode laser–assisted gum treatment for people with kidney transplants
Official title: Periodontal Status in Kidney Transplant Patients and the Effectiveness of Adjunctive Diode Laser Therapy
Run by Military Hospital 103 · NCT07532694 · Data updated 2026-11-12
This project will test whether adding a diode laser to standard deep dental cleaning (scaling and root planing) helps people with periodontitis who have had a kidney transplant.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Military Hospital 103 Academic / other |
| Locations | 2 sites (Hanoi, Hadong and 1 other locations) |
| Status | Recruiting |
| Started | December 9, 2025 |
| Main results expected | June 9, 2026 |
| Study ends | June 9, 2026 |
| Registry record updated | April 16, 2026 |
| Trial ID | NCT07532694 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who are medically stable kidney transplant recipients diagnosed with periodontitis and able to undergo non-surgical periodontal treatment and attend follow-up visits.
✕Probably not a fit
People who recently received periodontal treatment or systemic antibiotics, have an acute oral infection, are pregnant or clinically unstable, or cannot comply with scheduled visits are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, parallel-group trial will enroll 80 stable adult kidney transplant recipients with periodontitis and randomize them 1:1 to scaling and root planing (SRP) with adjunctive diode laser therapy or SRP alone. Clinical periodontal measures (CAL, PPD, BOP, GI, plaque indices) and radiographic alveolar bone changes will be collected at baseline, 1, 3, and 6 months. Systemic laboratory markers (platelet count, urea, creatinine, CRP) and subgingival microbiome profiles by 16S rRNA sequencing will be measured to capture biological effects. The study will compare whether the laser adjunct produces greater local periodontal and systemic improvements than SRP alone.
Why it matters
Potential benefit: If successful, adjunctive diode laser therapy could improve gum attachment, reduce pocket depths and local inflammation, and possibly lower systemic inflammation in kidney transplant recipients.
How similar studies have gone: Previous studies in general dental populations have shown mixed or modest benefits from diode-laser adjuncts to SRP, and using this approach specifically in kidney transplant recipients is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Kidney transplant recipients aged 18 years or older. * Diagnosis of periodontitis according to the study case definition. * Medically stable and able to undergo non-surgical periodontal treatment. * Willing and able to provide written informed consent and attend follow-up visits. Exclusion Criteria: * \- Periodontal treatment or systemic antibiotic use within the predefined exclusion window in the protocol. * Acute oral infection requiring urgent treatment. * Pregnancy or lactation, if excluded by the approved protocol. * Serious systemic condition or clinical instability judged by investigators to preclude study participation. * Inability to comply with study procedures or follow-up schedule.
Where it's running
-
103 Military Hospital
Hanoi, Hadong, Vietnam Recruiting -
Vietnam Military Medical University
Hanoi, Quận Hà Đông, Vietnam Recruiting
Study contacts
- Study coordinator: Thang V Dinh, Principal Investigator
- Email: bsdinhthang277@gmail.com
- Phone: +84971349066
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.