Pomegranate Peel Gel as an Add-on to SRP for Stage II–III Periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, triple-blind, placebo-controlled, split-mouth study will compare the effects of locally delivered pomegranate peel extract gel versus placebo gel when used as an adjunct to scaling and root planing in adults with Stage II–III periodontitis. Thirty-two participants will receive SRP in all eligible sites, with test sites receiving the pomegranate gel and contralateral sites receiving placebo. Outcomes include changes in probing pocket depth, clinical attachment level, plaque and gingival indices, bleeding on probing, and levels of MMP-8 in gingival crevicular fluid, measured at baseline, 1 month, 3 months, and 6 months. The study aims to determine if the adjunctive gel enhances periodontal healing beyond SRP alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 30 to 60 years.
* Systemically healthy individuals.
* Diagnosis of Stage II or Stage III periodontitis according to the 2018 Classification of Periodontal and Peri-Implant Diseases and Conditions.
* Presence of at least 20 natural teeth.
* Presence of at least two non-adjacent periodontal pockets (≥5 mm) located in different quadrants suitable for split-mouth allocation.
* Clinical attachment loss consistent with Stage II or Stage III periodontitis.
* Ability and willingness to comply with the study protocol and attend all follow-up visits.
* Provision of written informed consent.

Exclusion Criteria:

* Current smokers or users of any tobacco products.
* Pregnant or lactating women.
* Patients with systemic diseases known to affect periodontal status or wound healing (e.g., uncontrolled diabetes mellitus, immunodeficiency disorders, osteoporosis requiring antiresorptive therapy).
* Use of systemic antibiotics, corticosteroids, immunosuppressive agents, or non-steroidal anti-inflammatory drugs within the previous 3 months.
* Periodontal therapy received within the previous 6 months.
* History of allergy or hypersensitivity to pomegranate or any component of the study materials.
* Orthodontic treatment during the study period.
* Participation in another clinical trial within the previous 6 months.

Where it's running

• Faculty of Dental Medicine for Girls, Al-Azhar University
  Cairo, Cairo Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Gehad Samy, BDS, MSc, PhD
• Email: gehadasaad.26@azhar.edu.eg
• Phone: +201092710515

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.