Using injectable platelet-rich fibrin with bovine bone grafts to treat intrabony periodontal defects

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with stage III periodontitis and interproximal intrabony defects will undergo open flap debridement and receive either bovine-derived xenogenic bone graft mixed with i-PRF or the same graft mixed with saline. Clinical measures (for example probing pocket depth and defect area) and radiographic bone fill will be recorded and compared between the two groups. The aim is to determine whether i-PRF increases bone fill and reduces defect size versus graft alone. Findings will show whether adding this tissue-friendly biologic improves commonly used bovine xenograft outcomes for intrabony defects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female patients aged 18-65 years
* Patients with Stage III Periodontitis according to the AAP-EFP 2017 Periodontal Disease Classification
* PPD≥5 mm (if persistent 6 weeks after initial periodontal treatment)
* Intrabony defects in the interproximal region with 2 or 3 walls and a depth of at least ≥3 mm
* Non-smokers (those who smoke up to 10 per day may be included)

Exclusion Criteria:

* Patients under 18 years of age or older than 65 years of age
* Patients unable to consent
* Systemic diseases that could affect the success of surgery, such as uncontrolled diabetes
* Single-walled intrabony defects
* Those who have taken antibiotics, anti-inflammatory or immunosuppressive drugs, or birth control pills within the three months prior to the study
* Those who have received active periodontal treatment within the last six months and periodontal surgery within the last year
* Smoking more than 10 cigarettes per day
* Pregnancy or breastfeeding
* Those taking medications that affect the gums (e.g., calcium channel blockers, phenytoin or cyclosporine)
* Teeth with furcation defects
* Those undergoing active orthodontic treatment
* Those who are allergic to the biomaterials used in the study or prescribed medications

Where it's running

• Sağlık Bilimleri Üniversitesi
  Istanbul, Üsküdar, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Tuğçe Paksoy, Associate Professor
• Email: tugceakap86@hotmai.com
• Phone: +905534490452

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.