Gas6 and soluble MerTK in gum disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study enrolled 90 adults divided into three equal groups: stage III grade B periodontitis, gingivitis, and periodontally healthy individuals. Whole-mouth and site-specific clinical periodontal measures (probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index) were recorded. Gingival crevicular fluid and blood serum were collected and levels of Gas6 and soluble MerTK were measured by enzyme-linked immunosorbent assay (ELISA). Data were compared across groups using non-parametric statistical tests.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals without systemic diseases that may affect periodontal tissues (such as cardiovascular diseases, atherosclerosis, immune system disorders, rheumatoid arthritis, obesity, cancer, and diabetes)
* Individuals who have not used antibiotics within the last 3 months
* Individuals not taking any medications known to affect periodontal tissues
* Individuals without infectious diseases such as HIV, hepatitis B virus (HBV), or tuberculosis
* Individuals with at least 16 natural teeth, excluding third molars
* Individuals aged 18 years and older

Exclusion Criteria:

* Pregnant or lactating individuals
* Individuals who have received periodontal treatment within the last 6 months
* Current smokers

Where it's running

• Bolu Abant Izzet Baysal University Faculty of Dentistry
  Bolu, Bolu, Turkey (Türkiye) Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.