Prodentis probiotic alongside periodontal cleaning for periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Following root surface debridement (RSD), all participants start Prodentis twice daily for three months, after which one group stops and the other continues once daily until month 12; participants are reviewed every three months. Clinical periodontal measures (including pocket depth) and systemic immune-response markers will be recorded at each review to compare the two dosing schedules. Eligible adults must be non-pregnant, have more than 12 teeth, a diagnosis of stage III or IV periodontitis, and at least four residual pockets ≥5 mm after prior therapy. The trial is conducted at Universiti Malaya in Kuala Lumpur with follow-up visits through one year.

Why it matters

Who can join: the full rules

1. The subject has given their written consent to participate in the trial.
2. All subjects must be aged \>18 years old, not pregnant, and presented with number of teeth \> 12
3. Diagnosis for periodontitis Stage III and IV, will be according to 2017 the American Academy of Periodontology (AAP) and European Federation of Periodontology (EFP) classification
4. Has had 1 round of periodontal therapy within 3-6 months' time from recruitment date, and currently presented with at least 4 residual pockets with pocket depth 5mm and above.

Where it's running

• Universiti Malaya
  Kuala Lumpur, Kuala Lumpur, Malaysia Recruiting

Study contacts

• Principal investigator: Cheah — University of Malaya
• Study coordinator: Cheah
• Email: chiawei@um.edu.my
• Phone: +60379674806

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.