Using erythritol to improve gum health in severe periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of erythritol powder during non-surgical periodontal treatment for patients with severe periodontitis. Participants with gum pockets of 4 mm or more will receive either standard treatment or standard treatment combined with erythritol cleaning. The study aims to evaluate improvements in gum health indicators such as pocket depth, bleeding, and plaque levels over a period of 2 to 4 months. Factors like age, sex, smoking status, and diabetes will also be assessed for their influence on treatment outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults aged 18 years or older

Diagnosed with stage 3 or 4 periodontitis according to the 2017 classification

Presence of at least 12 natural teeth

Presence of periodontal pockets with probing depth ≥ 4 mm in non-adjacent teeth

Good general health or stable systemic conditions (e.g., controlled diabetes)

Exclusion Criteria:

Use of antibiotics or anti-inflammatory drugs within 3 months prior to treatment

Periodontal treatment in the previous 6 months

Pregnancy or breastfeeding

Current smokers of more than 10 cigarettes per day

Allergies or intolerance to erythritol or any materials used in the treatment

Systemic diseases or conditions that could influence periodontal healing (e.g., uncontrolled diabetes, immunodeficiency)

Use of medications known to affect periodontal tissues (e.g., phenytoin, cyclosporine, calcium channel blockers)

Where it's running

• University of L'Aquila
  L’Aquila, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.