Periodontal Infection and Inflammatory Markers in Missed Abortion

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, matched case-control study will compare 80 women with missed abortion to 80 women with ongoing uncomplicated pregnancies, all at 20 weeks of gestation or earlier. Each participant will undergo a periodontal exam and provide saliva for testing common periodontal bacteria and inflammatory biomarkers. Serum inflammatory markers will be measured from blood samples collected during routine obstetric care. Saliva samples are collected before periodontal probing to avoid contamination, and results will be analyzed to identify associations between oral health, bacterial burden, and systemic inflammatory markers with pregnancy outcome.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female participants aged 18-40 years Pregnancy at 20 weeks of gestation or earlier For the case group: diagnosis of missed abortion For the control group: ongoing uncomplicated pregnancy Provision of written informed consent

Exclusion Criteria:

* Detected fetal chromosomal or genetic abnormality Current smoking Alcohol use Diabetes mellitus Hypertension Autoimmune disease Antibiotic use within the previous 3 months Induced abortion Multiple pregnancy

Where it's running

• Necmettin Erbakan University Faculty of Medicine, Department of Obstetrics and Gynecology
  Konya, Konya, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Osman Babayiğit
• Email: obabayigit@erbakan.edu.tr
• Phone: +905063208474

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Mandibular molar furcation defects in advanced periodontitis: a regenerative treatment comparison

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.