Ibuprofen to reduce acute inflammation after one-stage non-surgical periodontal therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants receive baseline clinical exams, demographic data collection, standardized oral hygiene instructions, and baseline blood samples before scaling. One week later full‑mouth root surface debridement is performed in a single session by one periodontist, with the test group given 400 mg ibuprofen one hour before treatment and then three times daily for three days while the control group receives no ibuprofen. Blood biomarkers (hs-CRP, ProCT, IL‑6) are measured at baseline, one hour after therapy, and one week after therapy to compare acute inflammatory responses. Procedure time is recorded and standardized instruments and breaks are used to reduce operator and patient variability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. systemically healthy patients.
2. having a minimum of 20 teeth.
3. Generalized unstable periodontitis.
4. Pocket depth \[≥ 4 mm\].
5. All included participants should be adults aged more than 18 years .
6. smokers and non smokers

Exclusion Criteria:

1. Allergy or hypersensitivity to Ibuprofen or other NSAIDs.
2. current systemic anti-inflammatory or antibiotic therapy (\<3 months).
3. peptic ulcer disease.
4. recent periodontal therapy (\<3 months).
5. Asthma.
6. Renal impairment .
7. Hepatic impairment.
8. Severe cardiac disease (heart failure, hypertension (.
9. Bleeding disorders (e.g., hemophilia) or patients taking anticoagulants .
10. Any participant who had known or suspected high risk for tuberculosis, hepatitis B or HIV infections.
11. pregnant or lactating females.
12. those being unable to provide written informed consent.

Where it's running

• College of Dentistry, University of Baghdad
  Baghdad, Iraq Recruiting

Study contacts

• Study coordinator: Nabaa Ismail Ibrahim, B.D.S
• Email: naba.ismail2405@codental.uobaghdad.edu.iq
• Phone: 009647740580458

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.