Examining Salivary Cytokine Levels in Different Periodontal Conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the levels of specific cytokines, including GM-CSF, MIP-1α, and IL-1β, in the saliva of individuals with varying periodontal conditions: healthy gums, gingivitis, and periodontitis. A total of 60 systemically healthy participants will be recruited, with saliva samples collected and analyzed using enzyme-linked immunoassay (ELISA) to determine the inflammatory biomarkers present. The study seeks to understand the relationship between these cytokines and the pathogenesis of chronic inflammatory periodontal diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Systemically healthy participants.
* At least twenty permanent teeth present in the oral cavity.
* Non-smokers.
* No medication for continuous use.
* Not pregnant or breastfeeding.

Exclusion Criteria:

* Any oral or systemic disease.
* Regular use of systemic medications.
* Pregnancy or lactation.
* Received periodontal treatment within the last 6 months.
* Use of antibiotics, anti-inflammatory medications, or systemic corticosteroids in the last 6 months.
* Smokers.

Where it's running

• Izmir Katip Çelebi University Department of Periodontology
  Izmir, Çiğli, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Mehmet Sait Bilgiç, Research assistant
• Email: bilgicsait21@gmail.com
• Phone: +905512810621

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.