Clinical trial Recruiting at 1 site Observational Ages 30 and up

Treponema parvum in the bacteria under the gums of people with periodontitis

Official title: Prevalence of Treponema Parvum in Subgingival Microbiome of Patients With Periodontitis: A Case-Control Study

Run by University of Baghdad · NCT07443917 · Data updated 2026-11-12

This project will see if the bacteria Treponema parvum is present and how much of it is in gum-pocket samples from people with periodontitis.

More Periodontitis trials

Quick facts

Study typeObservational
Ages30 Years and up
SexAll
Enrollment112 (estimated)
SponsorUniversity of Baghdad
Academic / other
Locations1 site (Baghdad)
StatusRecruiting
StartedDecember 1, 2025
Main results expectedJune 1, 2026
Study endsSeptember 1, 2026
Registry record updatedMarch 2, 2026
Trial IDNCT07443917 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with a diagnosis of generalized periodontitis who have at least 20 teeth and who do not meet any exclusion criteria (for example, recent antibiotic/NSAID use, recent periodontal therapy, ongoing orthodontics, valve replacement requiring prophylaxis, or pregnancy/lactation) are ideal candidates.

Probably not a fit

People without periodontitis or those excluded due to recent antibiotics/NSAIDs, recent periodontal therapy, ongoing orthodontic treatment, valve replacement needing prophylactic antibiotics, or pregnancy/lactation are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will collect subgingival plaque samples using sterile paper points and record clinical periodontal measurements from enrolled participants. Samples will be analyzed by quantitative PCR (qPCR) to detect Treponema parvum and estimate its relative abundance in the biofilm. The study will relate T. parvum presence and quantity to clinical parameters such as pocket depth and attachment loss. Findings aim to clarify whether T. parvum is associated with periodontitis and could guide future diagnostic or treatment research.

Why it matters

Potential benefit: If a clear link is found, detecting T. parvum could help improve diagnosis or point to targets for more personalized periodontal treatment.

How similar studies have gone: Related microbiome and qPCR studies have associated other Treponema species with periodontitis, but the specific role and prevalence of T. parvum remain relatively understudied.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria: include participants who have at least 20 teeth and diagnosed as generalized periodontitis.

Exclusion Criteria: participants meeting any of the following criteria were excluded: (1) undergoing orthodontic treatment; (2) having a history of antibiotic/nonsteroidal anti-inflammatory drugs use within the last three months; (3) having a history of valve replacement who need prophylactic antibiotic coverage; (4) pregnant or lactating women; (5) having a history periodontal therapy within the last six month.

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Where it's running

  • College of Dentistry, University of Baghdad
    Baghdad, Iraq
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.