Salivary biomarkers in people with periodontitis and type 2 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional observational study will measure specific salivary biomarkers in 88 participants divided into four groups based on periodontal health and diabetes status. Calibrated clinicians will assess periodontal parameters and collect unstimulated saliva before any periodontal treatment. Biomarker levels will be quantified using ELISA assays to explore associations with periodontal disease, diabetes, and clinical measures of periodontitis. The work will be conducted at the Necmettin Erbakan University Department of Periodontology, enrolling adults aged 18 to 80 who meet the eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals aged 18 to 80 years. Individuals who apply to the Department of Periodontology, Faculty of Dentistry, Necmettin Erbakan University.

Individuals who agree to participate in the study and sign the informed consent form.

Presence of at least 20 teeth. For the periodontally healthy groups: diagnosis of periodontal health based on routine clinical and radiographic examination.

For the periodontitis groups: diagnosis of generalized Stage II or Stage III periodontitis based on routine clinical and radiographic examination according to the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions.

For the type 2 diabetes mellitus groups: diagnosis of type 2 diabetes mellitus. For the systemically healthy groups: absence of systemic diseases, including type 2 diabetes mellitus.

Exclusion Criteria:

* Periodontal treatment, including scaling and root surface debridement, within the last 6 months.

Antibiotic use within the last 6 months. Pregnancy or lactation. Presence of autoimmune diseases such as rheumatoid arthritis, familial Mediterranean fever, ankylosing spondylitis, Behçet disease, or psoriasis.

Presence of systemic diseases other than type 2 diabetes mellitus in the diabetes groups.

Presence of systemic diseases such as nephrotic syndrome, chronic renal disease, or cardiovascular disease.

Smoking 10 or more cigarettes per day.

Where it's running

• Necmettin Erbakan University Faculty of Dentistry, Department of Periodontology
  Konya, Konya, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Osman Babayiğit
• Email: obabayigit@erbakan.edu.tr
• Phone: +90 506 320 84 74

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.