Investigating how Kalirin affects bone health and periodontitis
Kalirin and Osteocyte Dysfunction: Implications Across Skeletal Sites and Experimental Periodontitis
This study is looking at how a protein called Kalirin affects bone health, especially in people with gum disease, by using mice to see what happens to their bones when Kalirin is missing.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11165657 on NIH RePORTER |
What this research studies
This research explores the role of Kalirin, a protein that influences bone cell function, particularly in osteocytes, which are crucial for maintaining bone health. The study uses a mouse model to examine how the absence of Kalirin affects bone density and structure, especially in the context of periodontal disease. By analyzing changes in bone mass and osteocyte health across various skeletal sites, the research aims to uncover the mechanisms behind bone loss and potential links to periodontitis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting bone health or those at risk for periodontal disease.
Not a fit: Patients who do not have issues related to bone density or periodontal health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing bone loss and improving treatments for periodontal disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of osteocytes in bone health, suggesting that this approach could yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Chester, Katie — Indiana University Indianapolis
- Study coordinator: Chester, Katie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.