Investigating how Kalirin affects bone health and periodontitis
Official title: Kalirin and Osteocyte Dysfunction: Implications Across Skeletal Sites and Experimental Periodontitis
Funded at Indiana University Indianapolis · NIH-11165657 · Data updated 2026-11-12
This study is looking at how a protein called Kalirin affects bone health, especially in people with gum disease, by using mice to see what happens to their bones when Kalirin is missing.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $54,774 |
| NIH project number | 1F30DE035004-01 |
| Project ID | NIH-11165657 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting bone health or those at risk for periodontal disease.
✕Less likely to help
Patients who do not have issues related to bone density or periodontal health may not benefit from this research.
What this research studies
This research explores the role of Kalirin, a protein that influences bone cell function, particularly in osteocytes, which are crucial for maintaining bone health. The study uses a mouse model to examine how the absence of Kalirin affects bone density and structure, especially in the context of periodontal disease. By analyzing changes in bone mass and osteocyte health across various skeletal sites, the research aims to uncover the mechanisms behind bone loss and potential links to periodontitis.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing bone loss and improving treatments for periodontal disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of osteocytes in bone health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Chester, Katie — Indiana University Indianapolis
- Study coordinator: Chester, Katie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.