Grade C Periodontitis in Young People: Understanding Who is at Risk
Official title: Susceptibility Patterns for Grade C Periodontitis in Young Individuals
Funded at University of Kentucky · NIH-11397347 · Data updated 2026-11-12
Aimed at figuring out why some young people get a severe form of gum disease and which factors make them more likely to progress.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | September 22, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,365,347 |
| NIH project number | 5U01DE031223-05 |
| Project ID | NIH-11397347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are young individuals with or at risk for Grade C periodontitis, especially those from diverse backgrounds and with a family history of the condition.
✕Less likely to help
Patients without the disease or with other forms of periodontitis not characterized as Grade C may not benefit from this study.
What this research studies
This project focuses on Grade C periodontitis in young individuals and looks at genetic, microbial, and inflammatory factors that may contribute to rapid disease progression. Researchers will study large groups of patients to identify who is most at risk, using genetic data and bacterial profiles from the mouth. The goal is to uncover clues that could lead to earlier diagnosis and better-targeted treatments for those affected.
Why it matters
Potential benefit: If successful, findings could help identify high-risk youths early and guide personalized prevention and treatment strategies.
How similar studies have gone: Prior work has identified genetic and microbial factors in periodontitis, but large-cohort data on Grade C/C-MIP in youth is limited, making this study novel yet building on established pathways.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Shaddox, Luciana Macchion — University of Kentucky
- Study coordinator: Shaddox, Luciana Macchion
Related research
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Grade C Periodontitis in Young People: Genetic Clues to a Severe, Early Condition
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.