Finding and confirming saliva biomarkers for early periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational diagnostic study will enroll adults with gingivitis or stage I periodontitis and collect saliva samples and clinical data at Shanghai Ninth People's Hospital. Researchers will use molecular and/or biomarker analysis of saliva alongside a patented AI-based self-detection app to identify candidate markers linked to early disease. The study aims to validate which saliva signals reliably indicate early periodontitis and compare AI predictions with clinical periodontal exams. Findings will inform whether the saliva test and app could be used for population-level screening or risk identification.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults between 18 and 40 years of age;
2. Diagnosed with varying degrees of periodontal disease, including gingivitis and stage I periodontitis;
3. Voluntarily agree to participate in the study, have signed the informed consent form, and are able to comply with the study protocol.

Exclusion Criteria:

1. Pregnant or breastfeeding women;
2. Individuals who have received antibiotic treatment within the past 3 months;
3. Individuals who have received periodontal treatment (including supragingival scaling) within the past 6 months;
4. Individuals with mucosal or salivary gland diseases (e.g., Sjögren's syndrome);
5. Individuals with severe systemic diseases, immune dysfunction, or health conditions that contraindicate surgery;
6. Individuals who are unwilling to cooperate with the study.

Where it's running

• Shanghai 9th people's hospital
  Shanghai, Shanghai Municipality, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.