Condition

Periodontitis (Stage 3) clinical trials and research

• 8Clinical trials
• 1New in 30 days
• 9Countries

Newest Periodontitis (Stage 3) clinical trials

All recruiting trials (8)

• Understanding links between severe periodontitis and gut bacteria and barrier function

  This observational study tests whether severe periodontitis is related to small intestinal bacterial overgrowth (SIBO) and changes in gut barrier biomarkers in adults.

  Recruiting Iuliu Hatieganu University of Medicine and Pharmacy · Cluj-Napoca · NCT07907224

• Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment

  This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.

  Recruiting Saglik Bilimleri Universitesi · Ankara and 2 other locations · NCT07822269

• Mandibular molar furcation defects in advanced periodontitis: a regenerative treatment comparison

  In people with advanced gum disease, this study tests two regenerative treatments for Hamp Class II furcation defects in lower molars to see which works better and whether CBCT imaging matches what clinicians find during surgery.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City · NCT07770256

• Omega-3s and low-dose aspirin for smokers with stage III periodontitis

  In adults who smoke and have stage III periodontitis, this study tests whether adding omega-3 fatty acids and a small amount of aspirin to standard cleaning helps improve gum health.

  Recruiting Al-Azhar University · Cairo · NCT07673185

• Bone substitutes with NIPSA for intrabony periodontal defects

  This study tests two bone substitutes (GTO and GenOs) used with the NIPSA technique to see which supports better gum and bone healing in adults with Stage III periodontitis.

  Recruiting at 2 sites University of Belgrade · Cagliari, Italy and 1 other locations · NCT07671963

• Probiotics with or without vitamin B12 added to non-surgical treatment for advanced periodontitis

  This study will see if taking a probiotic lozenge alone or together with vitamin B12 during non-surgical periodontal treatment changes the oral microbiome and helps adults with Stage III or IV periodontitis.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT07443410

• 3-month liquid platelet-rich fibrin treatment used during deep cleaning for stage II–IV periodontitis

  This 3-month test will see if flushing diseased gum pockets with your own liquid platelet-rich fibrin after deep cleaning helps healing for people with stage II–IV periodontitis.

  Recruiting Phase 2 Mahsa University · Jenjarum, Selangor · NCT07293962

• Twice-daily 30-minute Emanate Perio PODS after deep cleaning versus no treatment

  We will test whether using a protective periodontal hydrogel (Emanate Perio PODS) for 30 minutes twice a day after deep cleaning helps healing in adults with generalized Stage III periodontitis compared with no treatment.

  Recruiting at 9 sites McGuire Institute · Fullerton, California and 8 other locations · NCT06914596

Related topics

Quick answers

How many Periodontitis (Stage 3) clinical trials are recruiting right now?

8, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Malaysia (1 trial), Egypt (1 trial), United States (1 trial), Vietnam (1 trial), Turkey (Türkiye) (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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