Using low laser therapy and hyaluronic acid to improve periodontal treatment
Official title: The Effect of Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy in Patients With Periodontitis
Run by University of Ljubljana · NCT05907161 · Data updated 2026-11-12
This study is testing if adding low-level laser therapy or hyaluronic acid to regular gum treatment can help people with periodontitis heal better and reduce bacteria.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years to 70 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | University of Ljubljana Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Ljubljana) |
| Status | Recruiting |
| Started | June 9, 2023 |
| Main results expected | February 2026 |
| Study ends | February 2026 |
| Registry record updated | September 19, 2025 |
| Trial ID | NCT05907161 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are systemically healthy nonsmokers with untreated stage 3, grade B or C periodontal disease.
✕Probably not a fit
Patients with systemic diseases affecting periodontal health or those who have undergone recent periodontal treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of low-level laser therapy and hyaluronic acid as adjuncts to non-surgical periodontal therapy for patients with periodontitis. Participants will be divided into three groups: one receiving standard scaling and root planing, another receiving scaling and root planing with laser treatment, and the third receiving scaling and root planing with hyaluronic acid application. The aim is to evaluate the healing outcomes and bacterial reduction associated with each treatment protocol. The study will be conducted at the University Medical Center Ljubljana.
Why it matters
Potential benefit: If successful, this approach could enhance healing and improve outcomes for patients with periodontal disease.
How similar studies have gone: Previous studies have shown promising results with laser therapy in periodontal treatment, but the combination with hyaluronic acid is less explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * systemically healthy * nonsmokers * untreated periodontal disease (stage 3, grade B or C) * plaque index will not exceed 20% * at least 20 teeth in oral cavity Exclusion Criteria: * systemic diseases with impact on periodontal health * medication with impact on periodontal health * smokers * pregnant and lactating women * patients treated with antibiotics in the last 12 months * patients who had undergone periodontal treatment in the last year
Where it's running
-
Univerity Medical Center Ljubljana
Ljubljana, Slovenia Recruiting
Study contacts
- Study coordinator: Eva Skaleric, Dr.
- Email: eva.skaleric@gmail.com
- Phone: 0038640813432
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.