Clinical trial Recruiting at 1 site Interventional Ages 25 to 70

Using low laser therapy and hyaluronic acid to improve periodontal treatment

Official title: The Effect of Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy in Patients With Periodontitis

Run by University of Ljubljana · NCT05907161 · Data updated 2026-11-12

This study is testing if adding low-level laser therapy or hyaluronic acid to regular gum treatment can help people with periodontitis heal better and reduce bacteria.

More Periodontitis trials

Quick facts

Study typeInterventional
Ages25 Years to 70 Years
SexAll
Enrollment45 (estimated)
SponsorUniversity of Ljubljana
Academic / other
Drugs / interventionsradiation
Locations1 site (Ljubljana)
StatusRecruiting
StartedJune 9, 2023
Main results expectedFebruary 2026
Study endsFebruary 2026
Registry record updatedSeptember 19, 2025
Trial IDNCT05907161 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are systemically healthy nonsmokers with untreated stage 3, grade B or C periodontal disease.

Probably not a fit

Patients with systemic diseases affecting periodontal health or those who have undergone recent periodontal treatment may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of low-level laser therapy and hyaluronic acid as adjuncts to non-surgical periodontal therapy for patients with periodontitis. Participants will be divided into three groups: one receiving standard scaling and root planing, another receiving scaling and root planing with laser treatment, and the third receiving scaling and root planing with hyaluronic acid application. The aim is to evaluate the healing outcomes and bacterial reduction associated with each treatment protocol. The study will be conducted at the University Medical Center Ljubljana.

Why it matters

Potential benefit: If successful, this approach could enhance healing and improve outcomes for patients with periodontal disease.

How similar studies have gone: Previous studies have shown promising results with laser therapy in periodontal treatment, but the combination with hyaluronic acid is less explored.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* systemically healthy
* nonsmokers
* untreated periodontal disease (stage 3, grade B or C)
* plaque index will not exceed 20%
* at least 20 teeth in oral cavity

Exclusion Criteria:

* systemic diseases with impact on periodontal health
* medication with impact on periodontal health
* smokers
* pregnant and lactating women
* patients treated with antibiotics in the last 12 months
* patients who had undergone periodontal treatment in the last year

Where it's running

  • Univerity Medical Center Ljubljana
    Ljubljana, Slovenia
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.