How bacteria affect bone loss in periodontal disease
Osteocytes-bacteria interaction via NOD1 as a mechanism of bone loss in periodontitis
This study is looking at how certain bacteria that cause gum disease affect bone cells in your jaw, which can lead to tooth loss, and it aims to find new ways to help people who aren't getting better with current treatments.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11119127 on NIH RePORTER |
What this research studies
This research investigates the interaction between osteocytes, a type of bone cell, and specific bacteria that cause periodontal disease, which can lead to tooth loss. The study focuses on understanding how these bacteria trigger a response in osteocytes that results in bone loss. By examining the role of a receptor called NOD1, which detects bacterial components, the research aims to uncover the molecular mechanisms behind this process. The ultimate goal is to develop new strategies to prevent tooth loss in patients who do not respond to existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from periodontal disease, particularly those who have not responded to current treatment options.
Not a fit: Patients with periodontal disease who respond well to existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that prevent tooth loss in patients with periodontal disease.
How similar studies have performed: Previous research has shown that understanding the molecular mechanisms of bone loss in periodontal disease can lead to successful treatment strategies, indicating that this approach has potential.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Kittaka, Mizuho — Augusta University
- Study coordinator: Kittaka, Mizuho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.