Understanding the links between periodontitis, inflammation, and diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the pathogenic mechanisms involved in periodontitis and peri-implantitis by characterizing specific molecular markers that reflect the activity of these conditions. Biological samples such as plaque, saliva, and crevicular fluid will be collected from patients with advanced stages of periodontitis or peri-implantitis, as well as from healthy individuals. The study seeks to improve knowledge of the disease's pathogenesis, identify target molecules involved in tissue destruction, and determine molecular profiles of patients at risk. This research is non-interventional and will be conducted across multiple centers as part of routine care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Common criteria for all patient groups

* Patient \> 18 years old
* Patient affiliated to a social security system, beneficiary or beneficiary of a right other than AME
* Patient who speaks and understands French well enough to be able to read and understand the study information note.
* Patient who does not object to his participation in the study

Specific criteria:

\- Case Periodontitis: Patient with localized or generalized periodontitis, stage 3 or 4. The diagnosis of periodontitis is based on the elements found during the interview and clinical examination

\- Case peri-implantitis: Patients with at least 1 implant affected by peri-implantitis. Diagnosis is based on the findings of the interview, clinical examination and radiographic examination.

Control group:

Patient with gingival health on intact or reduced periodontium with no history of periodontitis or peri-implantitis and requiring surgical care such as dental avulsion and pre-prosthetic periodontal corrective/aesthetic surgeries (coronal elongation, neck alignment.)

Exclusion Criteria:

* Patients who have received antibiotic prophylaxis, antibiotic therapy, or anti-inflammatory treatment within 3 months prior to inclusion
* Pregnant or breastfeeding women
* Patient included in another interventional research protocol or in a period of exclusion.
* Patients under guardianship, curatorship or legal protection.
* Patient having expressed his opposition to participate in the research

Where it's running

• Service d'odontologie, hôpital Charles Foix
  Ivry-sur-Seine, France Recruiting
• Dentistry department- Rothschild hospital
  Paris, France Recruiting

Study contacts

• Study coordinator: Marjolaine GOSSET, Professor
• Email: marjolaine.gosset@aphp.fr
• Phone: +33 6 19 39 39 01

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Minimally invasive non-surgical treatment for peri-implantitis

  This test compares a gentler, minimally invasive non-surgical cleaning (MINST) with standard non-surgical cleaning for adults who have peri-implantitis to see which gives better gum, bone, and patient-reported outcomes over 12 months.

  Recruiting St. Anne's University Hospital Brno, Czech Republic · Brno · NCT07466966

• Investigating gene and microbiome profiles in gum diseases

  This study is trying to see how genes and bacteria in the mouth are related to gum diseases like periodontitis and peri-implantitis in adults to help improve diagnosis and treatment.

  Recruiting Karolinska Institutet · Stockholm · NCT06262035

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• Association Between Periodontitis and Dry Eye Disease in Adults

  This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.

  Recruiting University of Sulaimani · Sulaymaniyah, As Sulaymaniyah Governorate · NCT07873697

• Periodontal Infection and Inflammatory Markers in Missed Abortion

  Researchers will test whether gum infection and inflammation are linked to missed abortion in pregnant women with no major chromosomal problems.

  Recruiting Necmettin Erbakan University · Konya, Konya · NCT07864220

• Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease

  This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.

  Recruiting Abant Izzet Baysal University · Bolu, Central · NCT07826728

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.