Grade C Periodontitis in Young People: Genetic Clues to a Severe, Early Condition
Official title: Susceptibility Patterns for Grade C Periodontitis in Young Individuals
Funded at University of Kentucky · NIH-11606527 · Data updated 2026-11-12
A research team is studying why some young people develop a severe form of gum disease called Grade C periodontitis and how genetics and bacteria like Aa may contribute.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | September 22, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $21,000 |
| NIH project number | 3U01DE031223-05S1 |
| Project ID | NIH-11606527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are young individuals with or at risk for Grade C periodontitis, particularly those from diverse backgrounds and with family histories of the condition.
✕Less likely to help
Patients without this aggressive form of periodontitis or without access to affected dental care may not experience direct benefits.
What this research studies
This project looks at why certain young individuals from diverse backgrounds develop rapid, destructive gum disease and how their genes, immune responses, and mouth bacteria interact. Researchers plan to study large groups of affected youths to identify genetic variants and microbial patterns that accompany Grade C periodontitis. The study aims to translate findings into better risk prediction, earlier diagnosis, and more affordable, targeted care for patients who currently face high treatment needs. The work will involve collaboration with dental clinics and families to collect data and samples over several years.
Why it matters
Potential benefit: If successful, the research could lead to earlier identification of at‑risk youths and more effective, personalized treatments that improve long-term dental health.
How similar studies have gone: Previous studies have identified associations with Aa and genetic factors, but large-cohort confirmation in C/MIP is needed and this project aims to fill that gap.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Shaddox, Luciana Macchion — University of Kentucky
- Study coordinator: Shaddox, Luciana Macchion
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.