Understanding how immune cells affect bone healing in gum disease
Official title: Osteoimmunology of Retarded Bone Regeneration in Periodontitis
Funded at Nova Southeastern University · NIH-11145426 · Data updated 2026-11-12
This study is looking into why people with gum disease have a harder time healing their bones, and it needs your help to understand how certain immune cells might be getting in the way of recovery after treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project start | August 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $365,631 |
| NIH project number | 3R01DE029709-05S1 |
| Project ID | NIH-11145426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have been diagnosed with periodontitis.
✕Less likely to help
Patients with conditions unrelated to periodontitis or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the reasons behind slow bone healing in patients with periodontitis, a serious gum disease. It focuses on specific immune cell receptors that may disrupt the natural process of bone regeneration after treatment. By studying the interactions between these immune cells and bone-forming cells, the research aims to uncover the underlying molecular mechanisms that hinder recovery. Patients may be involved in providing samples or data to help identify these mechanisms and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance bone regeneration in patients with periodontitis.
How similar studies have gone: While the specific approach may be novel, previous research has shown that understanding immune mechanisms can lead to advancements in treating bone regeneration issues.
Where this research is happening
-
Nova Southeastern University
Fort Lauderdale-Davie, United States Active
Researchers
- Principal investigator: Kawai, Toshihisa — Nova Southeastern University
- Study coordinator: Kawai, Toshihisa
Related research
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Grade C Periodontitis in Young People: Genetic Clues to a Severe, Early Condition
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ICOS-Fc Therapy and Healing in Gum Disease (Periodontitis)
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Diabetes-Driven Changes in Dendritic Cells and T Cells in Gum Disease
This project studies how poorly controlled diabetes alters immune cells in periodontitis to worsen gum disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.